Table 4 List of orthologues described as drug and vaccine target candidates from different hematophagous parasites including Trematoda, Nematoda and Apicomplexa found in the EVs’ proteomic study using Sparicotyle chrysophrii, Protopolystoma xenopodis, Gyrodactylus salaris and Microcotyle sebastis proteomes as reference

Sparicotyle chrysophrii

Proteases

Leucine aminopeptidase (M17 family)

[52, 73, 105,106,107,108]

maker-contig_20098_pilon_pilon-augustus-gene−0.16-mRNA-1

Alanyl aminopeptidase (M1 family)

[73, 109]

maker-contig_6883_pilon_pilon-snap-gene−0.23-mRNA-1

Calpain

[52]

maker-contig_24278_pilon_pilon-snap-gene−0.33-mRNA-1

Carrier proteins

Ferritin

[84]

maker-contig_34520_pilon_pilon-augustus-gene−0.7-mRNA-1

Cytoskeleton

Dynein light chain

[52, 107]

maker-contig_41206_pilon_pilon-augustus-gene−0.3-mRNA-1

14–3-3 protein

[52, 107]

maker-contig_34517_pilon_pilon-snap-gene−0.19-mRNA-1

maker-contig_34517_pilon_pilon-snap-gene−0.19-mRNA-1

maker-contig_30173_pilon_pilon-snap-gene−0.10-mRNA-1

Heat shock protein 70

[52, 107]

augustus_masked-contig_13257_pilon_pilon-processed-gene−0.1-mRNA-1

augustus_masked-contig_5207_pilon_pilon-processed-gene−0.2-mRNA-1

Annexin

[52]

maker-contig_38531_pilon_pilon-exonerate_est2genome-gene−0.0-mRNA-1

maker-contig_29652_pilon_pilon-augustus-gene−0.2-mRNA-1

maker-contig_12610_pilon_pilon-snap-gene−0.5-mRNA-1

Tubulin

[110]

maker-contig_8332_pilon_pilon-augustus-gene−0.19-mRNA-1

snap_masked-contig_2563_pilon_pilon-processed-gene−0.25-mRNA-1

Antioxidant/ Defence/ Detoxification

Glutathione S-transferase

[52, 107]

maker-contig_7282_pilon_pilon-snap-gene−0.22-mRNA-1

Superoxide dismutase

[111]

maker-contig_45344_pilon_pilon-augustus-gene−0.2-mRNA-1

Metabolism

Enolase

[52, 107]

snap_masked-contig_11270_pilon_pilon-processed-gene−0.1-mRNA-1

Fructose-bisphosphate aldolase

[107]

[111]

maker-contig_31661_pilon_pilon-snap-gene−0.18-mRNA-1

Protopolystoma xenopodis

Cytoskeleton

Heat shock protein 70

[52, 107]

A0A448WN47

Tubulin

[110]

A0A448X3E2

A0A3S5FFD8

A0A448WX98

A0A448XD95

Gyrodactylus salaris

Cytoskeleton

Tubulin

[110]

Q709M4

Microcotyle sebastis

Cytoskeleton

Annexin

[52]

B3GQS3