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Fig. 1 | Parasites & Vectors

Fig. 1

From: Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway

Fig. 1

Abnormal pregnancy caused by T. gondii infection in mice was associated with Foxp3 and miRNAs. a Images are representative photographs of the uterus and fetus on 10 dpi and the abortion rate was analyzed (n = 4–5 mice). Compared with normal pregnancy in mice, obvious hemorrhage and necrosis in the mouse placenta along with fetal miscarriage were observed in the infected pregnant group (red arrow). b Pathological alterations of mouse placentas, which are composed of De, JZ and LZ, were observed by HE staining (n = 4–5 mice). A distinct placental hemorrhage occurred in the infected group (green arrow). c Foxp3 expression in the mouse placenta was measured by western blot and analyzed by Image J, normalized to GAPDH (n = 4 mice). d miRNAs in the placenta of mice with T. gondii (RH strain) infection were measured by real-time PCR, which is normalized to U6 (n = 4–5 mice). NP: normal pregnant mice; TI: Toxoplasma-infected pregnant mice. Data were presented as mean ± SD. Statistical analysis was conducted using two-tailed unpaired Student’s t-test (a, c, and d). *: P < 0.05; n.s.: P > 0.05

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Parasites & Vectors

ISSN: 1756-3305

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