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Fig. 7 | Parasites & Vectors

Fig. 7

From: Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway

Fig. 7

miR-7b bound to Sp1 3' UTR. a Schematic representation was shown for predicted binding sites of miR-7b and Sp1 3' UTR on the basis of the analysis of bioinformatics. The binding sites of miR-7b and Sp1 3' UTR were point mutated to construct the mutant plasmids. b, c The luciferase activities in EL4 cells that were co-transfected with recombinant plasmids containing the WT or MUT of Sp1 3' UTR and miR-7b mimics or inhibitors were assayed at 48 h post-transfection. Data were representative of the results of three independent experiments (mean ± SD). Statistical analysis was conducted using two-way ANOVA with Sidak’s multiple comparisons test (b and c). *: P < 0.05. n.s.: P > 0.05

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Parasites & Vectors

ISSN: 1756-3305

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