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Fig. 8 | Parasites & Vectors

Fig. 8

From: Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway

Fig. 8

Schematic representation of Foxp3 regulation by miR-7b-5p. T. gondii antigens elevated the miR-7b-5p promoter activity by inhibiting PPARγ expression. Additionally, miR-7b-5p induced by T. gondii antigens directly targets Sp1 3' UTR to repress its expression, thereby suppressing Foxp3 promoter activity

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Parasites & Vectors

ISSN: 1756-3305

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