Table 1 Geometric mean (3 skin snips) O. ochengi mf density+1 per 100 mg skin in cattle following a single treatment of UMF-078 at 150 mg/kg or 50 mg/kg and by the intramuscular or intraabomasal routes of administration.
treatment group | ID | 0 wpt | 1 wpt | 4 wpt | 12 wpt | 24 wpt | 42 wpt | 52 wpt | 72 wpt |
|---|---|---|---|---|---|---|---|---|---|
Control | 42 | 125.7 | 83.7 | 61.7 | 104.3 | 88.9 | 24.1 | 5.2 | 124.9 |
| Â | 46 | 5.1 | 135.8 | 256.5 | 60.3 | 72.7 | 7.8 | 16.2 | 139.3 |
| Â | 61 | 30.7 | 151.4 | 49.3 | 122.2 | 14.6 | 1237.0 | 32.9 | 47.0 |
150 mg/kg UMF-078 im | 74 | 2298.1 | 238.8 | 0.0 | 0.0 | 0.0 | 0.0 | - | 0.8 |
| Â | 88 | 1237.6 | 959.4 | 0.0 | 0.0 | 4.3 | 0.0 | - | 0.0 |
| Â | 92 | 3069.9 | 713.4 | 111.1 | 10.0 | 14.4 | 1.6 | - | 0.0 |
50 mg/kg UMF-078 im | 79 | 392.7 | 415.9 | 329.4 | 4.6 | 15.3 | 0.0 | 1.3 | 0.0 |
| Â | 80 | 556.8 | 57.6 | 25.6 | 26.1 | 13.4 | 30.6 | 24.0 | 0.0 |
| Â | 90 | 1998.6 | 934.5 | 164.7 | 357.6 | 73.0 | 10.0 | 6.2 | 20.8 |
150 mg/kg UMF-078 ia | 81 | 76.2 | 138.6 | 5.6 | 18.2 | 142.6 | 77.7 | - | 11.5 |
| Â | 85 | 309.9 | 17.8 | 1.2 | 0.0 | 118.5 | 139.4 | - | 359.1 |
| Â | 91 | 989.5 | 41.4 | 18.9 | 0.0 | 0.0 | * | * | * |
50 mg/kg UMF-078 ia | 82 | 1010.3 | 46.1 | 26.3 | 93.0 | 2.8 | 67.1 | - | 83.9 |
| Â | 84 | 3141.6 | 541.5 | 477.7 | 589.3 | 217.1 | 116.8 | - | 317.6 |
| Â | 93 | 1163.2 | 165.5 | 99.6 | 5.7 | 140.7 | 305.4 | - | 91.5 |