Table 3 Mean nodule diameters (mm), mean number of males per nodule (♂/nodule), median female motility score (♀ MOT) and mean female viability (as OD₄₉₂ values per 10 mm length; see text) (♀ OD₄₉₂) for O. ochengi recovered from cattle before and up to 52 weeks after a single dose of UMF-078 at 2 doses (50 and 150 mg/kg) and by 2 routes of administration (im = intramuscularly; ia = intra abomasally).

control

nodule diameter

8.7

8.0

7.5

6.3

7.1

♂/nodule

0.7

1.7

1.5

1.3

0.5

♀MOT

2.0

2.0

2.0

2.0

1.5

♀OD₄₉₂

0.22

0.21

0.32

0.15

0.10

150 mg/kg UMF 078 im

nodule diameter

8.5

6.5

6.0

3.3

ND

♂/nodule

0.2

0.7

0.1

0.0

♀MOT

2.0

1.5

0.0

0.0

♀ OD₄₉₂

0.29

0.12

0.01

0.0

50 mg/kg UMF 078 im

nodule diameter

7.7

7.7

6.3

5.9

5.6

♂/nodule

1.0

0.5

0.3

0.3

0.0

♀MOT

2.0

2.0

0.8

2.0

0

♀OD₄₉₂

0.31

0.13

0.06

0.11

0.17

150 mg/kg UMF 078 ia

nodule diameter

7.7

7.8

7.2

6.6

ND

♂/nodule

1.5

0.5

0.5

1.0

♀MOT

2.0

2.0

2.0

2.0

♀ OD₄₉₂

0.31

0.13

0.16

0.18

50 mg/kg UMF 078 ia

nodule diameter

7.5

8.5

7.3

7.2

ND

♂/nodule

0.5

0.3

0.8

0.6

♀MOT

2.0

2.0

2.0

2.0

♀ OD₄₉₂

0.14

0.15

0.14

0.14