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Table 1 Currently available treatments for human trypanosomiasis

From: Trypanosomiasis vector control in Africa and Latin America

  Date of
introduction
Days of treatment Likelihood of
serious side
effects
   T. cruzi gambiense rhodesiense  
   early late early late early late  
Suramine 1916 - - - - 40a - ++
Pentamidine 1940 - - 7 - - - +/-
Melarsoprol 1949 - - - 10–30b - 10–30b +++++
Nifurtimox 1967 30–60 - - 15–30c - - ++
Benznidazole 1972 30–60 - - - - - ++
Eflornithine 1990 - - - 7–14d - - ++
  1. a Suramine: 1 injection per week for 5 weeks
  2. b Melarsoprol: new regime being developed of 1 daily injection for 10 days
  3. c Nifurtimox: not yet registered for use against gambiense, but is being used on compassionate grounds when other treatments fail
  4. d Eflornithine: 4 intravenous perfusions per day