Skip to main content

Table 3 Expression change of the genes related to cell cycle regulation after Trichinella infection

From: Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair

Gene Name

Description

Expression change

  

Ts

Tp a

retinoblastoma 1 (Rb1)

negative regulation of cell growth and progression via cell cycle

↑

↑

ring-box 1 (Rbx1)

cell cycle regulation of G1/S transition

↑

↑

cyclin-dependent kinase inhibitor 1A (P21)

cell cycle arrest; negative regulation of cell proliferation

↑

↑

cyclin-dependent kinase 4 (CDK4)

cell cycle; cell proliferation; G1/S transition

↑

↑

G0/G1 switch gene 2 (G0s2)

regulation of progression through cell cycle

↓

↓

Granulin

Mitogen, cell cycle progression, cell motility

↑

NC a

cyclin A2

G1/S and G2/M transitions, regulator of CDC2 or CDK2 kinases

↑

NC

cyclin C

regulation of cell cycle

↑

NC

Cyclin D3

cell cycle G1/S transition, regulator of CDK4 or CDK6

↑

UR a

Cyclin D2

cell cycle G1/S transition, regulator of CDK4 or CDK6

↑

UR

Cyclin B2

Cell cycle regulation, TGF beta-mediated cell cycle control

↑

UR

cyclin E1

G1/S transitions, regulator of CDC2

↑

UR

myeloblastosis oncogene (Myb)

regulation of cell cycle; G1/S transition of mitotic cell cycle

NC

↑

CDC20

regulation of cell cycle

↑

UR

cyclin-dependent kinase inhibitor 1B (P27)

controls cell cycle progression at G1, prevents activation of cyclin E-CDK2 or cyclin D-CDK4 complexes

↑

UR

Cullin 3 (Cul3)

Cell cycle arrest, G1/S transition of cell

NC

↓

Cell division cycle 5 (Cdc5)

positive regulator of cell cycle G2/M progression

NC

↓

  1. a: Ts: Trichinella spiralis; Tp: T. pseudospiralis
  2. b: NC: no change
  3. c: UR: no result