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Figure 3 | Parasites & Vectors

Figure 3

From: Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases

Figure 3

Phylogenetic relation of Ixodes ricinus gut-associated cysteine peptidases (clan CA, family C1) to selected representatives of the papain family. The tree was reconstructed by the Neighbor-joining method using amino acid sequences spanning across the homologous domains of mature enzymes. The horizontal bar represents a distance of 0.1 substitutions per site. Numbers at the branches display bootstrap support. Cathepsins B: Homo sapiens (AAH95408), Rattus norvegicus (P00787), Ixodes ricinus (ABO26563), Haemaphysalis longicornis (BAF43801), Schistosoma mansoni (P25792), Schistosoma japonicum (P43157); Cathepsins L: H. sapiens (M20496), R. norvegicus (AAH63175), I. ricinus (ABO26562), Boophilus microplus (AF227957), S. mansoni (CathL1 (Z32529), CathL2 (U07345)), S. japonicum (CathL1 (U38476), CathL2 (U38475)), Trypanosoma cruzii (P25779); Cathepsins C: H. sapiens (X87212), R. norvegicus (D90404), I. ricinus (ABV29335), S. mansoni (Z32531), S. japonicum (U77932).

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