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Figure 1 | Parasites & Vectors

Figure 1

From: In silico analysis of the cyclophilin repertoire of apicomplexan parasites

Figure 1

Unrooted phylogram representing evolutionary relationship between apicomplexan Cyps. (A) Sequences of putative Cyp domains were aligned using ClustalW2 and an unrooted maximum likelihood tree was calculated using PhyML [34]. For comparison, the human and fission yeast Cyp repertoires were included in the analysis. Statistical support of nodes calculated as likelihood ratios is indicated for those nodes with at least 70% support. Cyp subfamilies as revealed by phylogenetic analysis and domain architecture are highlighted by different colors. The dark gray background in the lower part of the figures marks Cyp subfamilies containing Cyp_ABH type or related domains. (B) Subtree from phylogram presented only compressed in (A). The scale bars represent 0.5 substitutions per amino acid position. Ch, C. hominis; Tg, T. gondii; Pf, P. falciparum; Py, Plasmodium yoelii; Bb, B. bovis; Ta, T. annulata; Tp, T. parva; Hs, Homo sapiens; Sp, Schizosaccharomyces pombe. The identity of individual protein sequences used for analyses can be obtained from Tables 1–6 and Table S1 in Additional file 1.

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