Figure 9

Phylogram showing evolutionary relationships for Cyp and FKBP domains of FCBPs and CFBPs. Cyp domains (A) and FKBP domains (B) of FCBPs and CFBPs were aligned with related domains identified by BLAST analyses in archaebacteria, eubacteria and eukaryotes. Unrooted maximum likelihood phylograms were calculated using PhyML [34]. Statistical support for branches is given as approximate likelihood ratio at the nodes. Only likelihoods of at least 70% are presented. FCBPs of apicomplexa, ciliophora, oomyceta, chlorophyta, and archaebacteria are highlighted in red, orange, yellow, green, and purple, respectively. CFBP of spirochaetes and flavo-/proteobacteria are marked in different blue tones. Species abbreviations: Ta, Theileria annulata; Tp, Theileria parva; Tg, Toxoplasma gondii; Bb, Babesia bovis; Gj, Griffithsia japonica; Pt, Paramecium tetraurelia; Tt, Tetrahymena thermophila; Cw, Crocosphaera watsonii; Pca, Phytophora capsici; Mm, Mus musculus; Eh, Entamoeba histolytica; Ot, Ostreococcus tauri; Tc, Trypanosoma cruzi; Ss, Synechocystis spec.; Cl, Codonopsis lanceolata; Cb, Caenorhabditis briggsae; Bm, Blastupirellula marina; Sa, Stigmatella aurantiaca; Ar, uncultured archaeon GZfos18C8; Cbe, Clostridium beijerincki; Mb, Methanococcoides burtonii; Gf, Gramella forsetii; Ca, Croceibacter atlanticus; Fb, Flavobacteriales bacterium; Fba, Flavobacteria bacterium; Cs, Celluphaga spec. MED134; Lb, Leeuwenhoekiella blandensis; Dp, Desulfotalea psychrophilia; Td, Treponema denticulata; Bh, Borrelia hermsii; Hm, Haloarcula marismortui; Haloquadrantum walsbyi; Mg, Magnaporthe grisea; Pn, Phaeosphaeria nodorum; Aa, Aedes aegyptii; Lm, Leishmania major; Tn, Tetraodon nigroviridis; Py, Plasmodium yoelii; Pc, Plasmodium chabaudi; Pb, Plasmodium berghei; Pf, Plasmodium falciparum; Ec, Entodinium caudatum; Te, Trichodesmium erythraeum; No, Nitrosococcus oceani; Ps, Polaromonas spec. Js666; Yl, Yarrowia lipolytica; Gs, Geobacter spec. FRC-32; Mba, Methanosarcina barkeri; Mbu, Methanococcoides burtonii; Mt, Methanotherococcus thermolithotrophicus; Ma, Methanosarcina acetivorans; Mma, Methanoculleus marisnigri; Cf, Chlorobium ferrooxidans.