In silico analysis of the cyclophilin repertoire of apicomplexan parasites

Parasites & Vectors

Table 2 Toxoplasma gondii cyclophilin proteins.

Name	Accession-no.	Amino acids	MW^a (kDa)	Motifs/Domains^b
Tg Cyp18.7^e	EEA99351^c	163	18.7	Cyp
Tg Cyp18.8	EEB00823^c	172	18.8	Cyp
Tg Cyp19.6	AAA17997^c	179	19.6	SP, Cyp
Tg Cyp21	EEA98581^c	195	21.0	Cyp
Tg Cyp21.7	EEB01220^c	197	21.7	Cyp
Tg Cyp23	EEB02074^c	211	23.0	Cyp
Tg Cyp31.8^e	TGGT1_052840^d	283	31.8	Mito, Cyp
TgCyp36.7^f	ORF^f	335	36.7	Cyp
Tg Cyp38.2	EEB00661^c	348	38.2	Cyp
Tg Cyp64.5	EEA99592^c	575	64.5	Cyp
Tg Cyp66.2	EEB00778^c	587	66.2	Cyp, SYF2
Tg Cyp66.3^g	EEA99267^c	592	66.3	Cyp^e, RRM
Tg Cyp72.9	EEB03226^c	612	72.9	RING, Cyp
Tg Cyp86	EEB02781^c	764	86	WD40, Cyp
Tg FCBP57.3	AAX51680^c	521	57.3	FKBP, TRP, Cyp

^aMW, molecular weight.
^bCyp, cyclophiln domain; SP, signal peptide; Mito, mitochondrial targeting sequence; SYF2, SYF2 splicing factor; RRM, RNA recognition motif; RING, RING finger domain; WD40, WD40 repeat; FKBP, FK506-binding domain; TRP, Tetratricopeptide repeat.
^{c, d}Accession number in Entrez Protein and ToxoDB, respectively.
^eTg Cyp18.7 in Entrez Protein contains only an NH₂-terminally truncated Cyp domain. In all further analyses, Tg Cyp31.8 was used instead. This deduced protein contains the same COOH-terminus but additional NH₂-terminal sequences.
^fTg Cyp36.7 was deduced from the T. gondii VEG genome sequence, chromosome VIIa, between position 1860418 and 1864189.
^gTg Cyp66.3 contains a protein containing a RNA recognition motif. However, the Cyp domain appears to be disrupted, maybe due to misprediction of the ORF.

ISSN: 1756-3305