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Table 2 Reference compound IC50's from reference compounds diluted in water, HMI-9 medium with and without FCS and PBS.

From: A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427

Compound

PBS

Water

FCS

No FCS

Pentamidine

13.42 ± 7.5

57.78 ± 40

9.23 ± 0.71

7.56 ± 2.8

Diminazine

65.98 ± 1.7

140.6 ± 79

65.79 ± 21

62.46 ± 21.3

Staurosporine

10.99 ± 1.3

12.27 ± 3.0

2.43 ± 0.59

5.22 ± 1.1

  1. IC50 values of compounds in variations of compound dilution media were determined in the luciferase assay and calculated from duplicate samples, expressed as ± SD, in nM.
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Parasites & Vectors

ISSN: 1756-3305

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