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Table 1 Comparative pharmacokinetics of moxidectin (MOX) and ivermectin (IVM) after oral administration in horses expressed as mean (± SD)

From: Moxidectin: a review of chemistry, pharmacokinetics and use in horses

  IVM MOX
Dose (mg/kg) 0.2 0.4
Cmax (μg/mL) 44.0 (± 23.1) 70.4 (± 10.7)
Tmax (day) 0.38 (± 0.24) 0.37 (± 0.19)
T1/2 elim (day) 4.25 (± 0.29) 23.11 (± 11.0)
AUC 0-t (μg/day/mL) 132.7 (± 47.3) 363.6 (± 66.0)
  1. Cmax = Maximum concentration
  2. Tmax = Time for maximum concentration
  3. T1/2 = Terminal half-life
  4. AUC = Area Under the concentration vs. time Curve