Table 1 Proteins in essential for survival processes, mitochondrial changes and effectors associated with trypansomatid apoptosis

Proteins associated with the cell-cycle

Prohibitin (T. brucei)

RACK (T. brucei)

QM (T. brucei)

PKC (L. donovani)

GSK-3 (L. donovani)

CRK3 (L. donovani)

Respiration and ΔΨm

Increase, Decrease

Proteases

Cathepsin-like proteases (CPA, CPB, CPC)

(L. major, L. mexicana)

Proteins associated with proliferation and cell division

Centrin (L. donovani)

EF-1α (T. cruzi)

Mitochondrial membrane permeability

ROS by lipid peroxidation^b

ΔΨm by mitochondrial matrix condensation^a

Bcl-2 functional homologues^b

Proteasomal proteases

(L. amazonensis)

Proteins involved in DNA replication

Topoisomerases (Leishmania spp.)

Mitochondrial release of pro-apoptotic proteins

Cytochrome c ^c

EndoG

Metacaspases

(T. cruzi, L. donovani)

Proteins involved in nucleocytoplasmic transport

Ran (T. brucei)

RanBP1 (T. brucei)

CAS (T. brucei)

NTF-2 (T. brucei)

ΔΨm, ROS and Ca2+ interplay

Trigger → Cytosolic Ca2+ elevation → Ca2+ entry into mitochondrion → Dissipation of ΔΨm → ROS

Nucleases

EndoG

(Leishmania spp.)

Proteins in cytoskeletal dynamics

Tubulins ^a

(L. donovani, T. brucei)

Trigger → ROS → lipid peroxidation-→ elevation of cytosolic Ca2⁺ → Dissipation of ΔΨm

TatD-like endonuclease

(L. donovani)

Proteins in other processes

SIR2 deacetylase

(L. infantum)

Trigger → ROS → ΔΨm → intracellular Ca2+ elevation

Flap-endonuclease-1

(L. donovani)