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Table 1 Proteins in essential for survival processes, mitochondrial changes and effectors associated with trypansomatid apoptosis

From: Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

Proteins in essential processes associated with apoptosis Mitochondrial changes associated with apoptosis Effectors of apoptosis
Proteins associated with the cell-cycle
Prohibitin (T. brucei)
RACK (T. brucei)
QM (T. brucei)
PKC (L. donovani)
GSK-3 (L. donovani)
CRK3 (L. donovani)
Respiration and ΔΨm
Increase, Decrease
Cathepsin-like proteases (CPA, CPB, CPC)
(L. major, L. mexicana)
Proteins associated with proliferation and cell division
Centrin (L. donovani)
EF-1α (T. cruzi)
Mitochondrial membrane permeability
ROS by lipid peroxidationb
ΔΨm by mitochondrial matrix condensationa
Bcl-2 functional homologuesb
Proteasomal proteases
(L. amazonensis)
Proteins involved in DNA replication
Topoisomerases (Leishmania spp.)
Mitochondrial release of pro-apoptotic proteins
Cytochrome c c
(T. cruzi, L. donovani)
Proteins involved in nucleocytoplasmic transport
Ran (T. brucei)
RanBP1 (T. brucei)
CAS (T. brucei)
NTF-2 (T. brucei)
ΔΨm, ROS and Ca2+ interplay
Trigger → Cytosolic Ca2+ elevation → Ca2+ entry into mitochondrion → Dissipation of ΔΨm → ROS
(Leishmania spp.)
Proteins in cytoskeletal dynamics
Tubulins a
(L. donovani, T. brucei)
Trigger → ROS → lipid peroxidation-→ elevation of cytosolic Ca2+ → Dissipation of ΔΨm TatD-like endonuclease
(L. donovani)
Proteins in other processes
SIR2 deacetylase
(L. infantum)
Trigger → ROS → ΔΨm → intracellular Ca2+ elevation Flap-endonuclease-1
(L. donovani)
  1. a. Apoptosis is triggered by agents interfering with tubulin polymerization
  2. b. Awaits confirmation
  3. c. Unknown function in trypanosomatid apoptosis
  4. In brackets, the genus or the species involved.