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Figure 3 | Parasites & Vectors

Figure 3

From: Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis

Figure 3

Phylogenetic and synteny relationships between B. bovis , T. annulata and T. parva C1 cysteine peptidases. A. Phylogenetic relationships of cysteine peptidases of B. bovis and their Theileria annulata and T. parva orthologs/paralogs as analyzed by neighbor joining. The tree is drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. The evolutionary distances were computed using the Poisson correction method. Deletion of all positions containing gaps and missing data resulted in a total of 171 positions in the final dataset. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1000 replicates) is shown next to the branches. The GenBank reference sequence number of each protein is shown. Bb: B. bovis; Ta: Theileria annulata; Tp: T. parva; Lm: Leishmania major cathepsin L-like protein is used as outgroup. B. Synteny studies of the bovipain-2 encoding genome region with the ortholog/paralogs encoding regions of T. annulata and T. parva. Lines that connect the catalytic region of the bovipain-2 [GenBank: XP_001610695] encoding gene and the catalytic regions of related cysteine proteinases encoding genes of T. annulata, and T. parva represent high scoring sequence pairs (HSPs). Reference protein sequence numbers from right to left: T. annulata, [GenBank: XP_954970, XP_954971, XP_954972, XP_954973, XP_954974, XP_954975, XP_954976], and T. parva, [GenBank: XP_763298, XP_763298, XP_763298, XP_763298, XP_763298, XP_763298]. A small ORF encoding a hypothetical protein [GenBank XP_001610696] in B. bovis has corresponding HSPs in T. annulata and T. parva. In T. annulata this ORF has not been annotated.

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