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Table 1 A comparison of the characteristics of immunomics protein microarrays with conventional proteomic approaches

From: Schistosomiasis vaccine discovery using immunomics

Characteristic

Protein Microarrays

Conventional Proteomic Approaches

Protein Structure

Can be limited

Present, depending on methods

Protein Abundance

Not affected

Low abundance proteins lost

Protein Identification

Not affected

Difficult

Pathogen Protein Extraction

Not applicable (uses DNA/cDNA)

Difficult

Protein localisation

Not affected

Membrane proteins difficult to extract and detect

Technical difficulty

Low

High