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Table 1 STUDY #1: Geometric mean flea counts and percent efficacy relative to nontreated controls for cats treated with an 10% w/v imidacloprid + 1.0% w/v moxidectin topical solution or a selamectin (6% w/v) topical spot-on, 24 and 48 hours after treatment or infestation.

From: Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats

  Day 0 Day 7 Day 14 Day 21 Day 28
Treatment 1 Mean # of fleas 2,3 % efficacy 4 Mean # of fleas % efficacy Mean # of fleas % efficacy Mean # of fleas % efficacy Mean # of fleas % efficacy
24 hours post-treatment or infestation           
Controls 79.2a   67.4a   64.1a   68.6a   52.6a  
Selamectin 0.8b 99.0 0.0b 100 1.1b 98.3 6.0b 91.2 6.8b 87.1
Imidacloprid-Moxidectin 0.1b 99.8 0.2b 99.6 0.0b 100 5.4b 92.1 0.6c 98.9
48 hours post-treatment or infestation           
Controls 72.7a   69.7a   53.5a   56.8a   52.9a  
Selamectin 0.0b 100 0.0b 100 0.0b 100 0.5b 99.1 0.9b 98.3
Imidacloprid-Moxidectin 0.0b 100 0.0b 100 0.1b 99.7 0.6b 99.0 1.7b 96.8
  1. 1Each of 5 cats in the control group received no treatment. Each of 5 cats in the 10% w/v imidacloprid + 1.0% w/v moxidectin or selamectin (6%w/v) treatment groups were administered the topical spot-ons, according to label directions on Day 0.
  2. 2Each cat was infested with 100 adult Ctenocephalides felis from the KS1 strain on days -2, 7, 14, 21 and 28.
  3. 3Geometric mean # of fleas recovered from cats per treatment group.
  4. 4% efficacy = ((geometric mean count control-geometric mean count treatment)/geometric mean count treatment) × 100
  5. a, b, c geometric means within a column with unlike letter superscripts are significantly different (P < 0.05).