Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats

Table 1 STUDY #1: Geometric mean flea counts and percent efficacy relative to nontreated controls for cats treated with an 10% w/v imidacloprid + 1.0% w/v moxidectin topical solution or a selamectin (6% w/v) topical spot-on, 24 and 48 hours after treatment or infestation.

	Day 0		Day 7		Day 14		Day 21		Day 28
Treatment ¹	Mean # of fleas ^2,3	% efficacy ⁴	Mean # of fleas	% efficacy	Mean # of fleas	% efficacy	Mean # of fleas	% efficacy	Mean # of fleas	% efficacy
24 hours post-treatment or infestation
Controls	79.2a		67.4a		64.1a		68.6a		52.6a
Selamectin	0.8b	99.0	0.0b	100	1.1b	98.3	6.0b	91.2	6.8b	87.1
Imidacloprid-Moxidectin	0.1b	99.8	0.2b	99.6	0.0b	100	5.4b	92.1	0.6c	98.9
48 hours post-treatment or infestation
Controls	72.7a		69.7a		53.5a		56.8a		52.9a
Selamectin	0.0b	100	0.0b	100	0.0b	100	0.5b	99.1	0.9b	98.3
Imidacloprid-Moxidectin	0.0b	100	0.0b	100	0.1b	99.7	0.6b	99.0	1.7b	96.8

¹Each of 5 cats in the control group received no treatment. Each of 5 cats in the 10% w/v imidacloprid + 1.0% w/v moxidectin or selamectin (6%w/v) treatment groups were administered the topical spot-ons, according to label directions on Day 0.
²Each cat was infested with 100 adult Ctenocephalides felis from the KS1 strain on days -2, 7, 14, 21 and 28.
³Geometric mean # of fleas recovered from cats per treatment group.
⁴% efficacy = ((geometric mean count control-geometric mean count treatment)/geometric mean count treatment) × 100
a, b, c geometric means within a column with unlike letter superscripts are significantly different (P < 0.05).

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