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Table 2 STUDY #2: Geometric mean flea counts and percent efficacy relative to nontreated controls for cats treated with an 10% w/v imidacloprid + 1.0% w/v moxidectin topical solution or a selamectin (6%w/v) topical spot-on, 12 and 24 hours after treatment or infestation.

From: Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats

  Day 0 Day 7 Day 14 Day 21 Day 28
Treatment 1 Mean # of fleas 2,3 % efficacy 4 Mean # of fleas % efficacy Mean # of fleas % efficacy Mean # of fleas % efficacy Mean # of fleas % efficacy
12 hours post-treatment or infestation           
Controls 52.2a   62.2a   56.4a   47.5a   48.4a  
Selamectin 16.0b 69.4 0.6b 99.1 5.3b 90.6 18.6a 60.9 20.6a 57.3
Imidacloprid-Moxidectin 0.0c 100.0 0.0c 100.0 0.2c 99.7 0.7b 98.5 4.7b 90.2
24 hours post-treatment or infestation           
Controls 45.1a   56.3a   52.4a   47.1a   49.6a  
Selamectin 1.6b 96.4 0.0b 100.0 0.1b 99.7 0.5b 99.0 2.3b 95.3
Imidacloprid-Moxidectin 0.0c 100.0 0.0b 100.0 0.1b 99.8 0.0b 100.0 1.2b 97.5
  1. 1Each of 8 cats in the control group received no treatment. Each of 8 cats in the 10% w/v imidacloprid + 1.0% w/v moxidectin or selamectin (6%w/v) treatment groups were administered the topical spot-ons, according to label directions on Day 0.
  2. 2Each cat was infested with 100 adult Ctenocephalides felis from the KS1 strain on days -2, 7, 14, 21 and 28.
  3. 3Geometric mean # of fleas recovered from cats per treatment group.
  4. 4% efficacy = ((geometric mean count control -geometric mean count treatment)/geometric mean count treatment) × 100
  5. a, b, c geometric means within a column with unlike letter superscripts are significantly different (P < 0.05).