Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats

Table 2 STUDY #2: Geometric mean flea counts and percent efficacy relative to nontreated controls for cats treated with an 10% w/v imidacloprid + 1.0% w/v moxidectin topical solution or a selamectin (6%w/v) topical spot-on, 12 and 24 hours after treatment or infestation.

	Day 0		Day 7		Day 14		Day 21		Day 28
Treatment ¹	Mean # of fleas ^2,3	% efficacy ⁴	Mean # of fleas	% efficacy	Mean # of fleas	% efficacy	Mean # of fleas	% efficacy	Mean # of fleas	% efficacy
12 hours post-treatment or infestation
Controls	52.2a		62.2a		56.4a		47.5a		48.4a
Selamectin	16.0b	69.4	0.6b	99.1	5.3b	90.6	18.6a	60.9	20.6a	57.3
Imidacloprid-Moxidectin	0.0c	100.0	0.0c	100.0	0.2c	99.7	0.7b	98.5	4.7b	90.2
24 hours post-treatment or infestation
Controls	45.1a		56.3a		52.4a		47.1a		49.6a
Selamectin	1.6b	96.4	0.0b	100.0	0.1b	99.7	0.5b	99.0	2.3b	95.3
Imidacloprid-Moxidectin	0.0c	100.0	0.0b	100.0	0.1b	99.8	0.0b	100.0	1.2b	97.5

¹Each of 8 cats in the control group received no treatment. Each of 8 cats in the 10% w/v imidacloprid + 1.0% w/v moxidectin or selamectin (6%w/v) treatment groups were administered the topical spot-ons, according to label directions on Day 0.
²Each cat was infested with 100 adult Ctenocephalides felis from the KS1 strain on days -2, 7, 14, 21 and 28.
³Geometric mean # of fleas recovered from cats per treatment group.
⁴% efficacy = ((geometric mean count control -geometric mean count treatment)/geometric mean count treatment) × 100
a, b, c geometric means within a column with unlike letter superscripts are significantly different (P < 0.05).