Genetic diversity of transmission-blocking vaccine candidates Pvs25 and Pvs28 in Plasmodium vivax isolates from Yunnan Province, China

Table 4 Amino acid variations of Pvs28 among worldwide isolates

	SS		EGF-1		EGF-2								EGF-3				EGF-4		RR					THR
Country	0 0 5	0 1 4	0 5 2	0 5 3	0 6 5	0 7 9	0 8 1	0 8 7	0 9 5	0 9 8	1 0 5	1 0 6	1 1 0	1 1 3	1 1 6	1 4 0	1 5 9	1 7 9	1 9 1	2 0 8 *	2 1 0 #	2 1 4 $	GSGGE/D	2 2 1 &	2 2 2 @	Ref.
Sal-I	H	V	M	A	T	V	A	D	G	L	E	V	N	N	L	T	K	G	G	D	G	S	6	V	I	AAC99770
Iran	•	•	L	•	T/K	•	•	•	•	•	•	•	•	•	•	S	•	•	•	•	•	•	4-6	•	•	[24]
Mexico	•	•	L	•	•	•	•	N	•	•	•	•	Y	•	•	S	•	•	•	•	•	•	5-6	•	•	[31]
Bangladesh	•	•	M/L	•	T/K	•	•	•	•	L/I	•	•	•	N/S	L/V	T/S	K/ R	•	•	•	•	•	5-7	•	I/ M	[25]
Thailand	•	•	M/L	A/V	T/K	•	A/V	•	G/N	L/I	E/K	V/E	•	•	L/V	T/S	•	•	•	•	•	•	5-7	•	•	[15]
India	•	•	L	•	K	•	•	•	•	•	•	•	•	•	•	S	•	•	•	•	•	•	4	•	•	[25]
India	H/T/Y	•	M/L	A/V	T/K	V/E	•	•	•	L/I	E/K	•	•	•	L/V	T/S	•	•	D	D/G	G/R	S/ T	3-6	V/L	I/M	[26]
S Korea	•	•	L	•	•	•	•	•	•	•	•	•	•	•	•	S	•	G/ E	G/ R	•	•	•	6	•	•	[22]
China (YN)	•	V/L	M/L	•	•	•	•	•	•	L/I	E/K	•	•	•	L/V	T/S	•	G/E	•	•	•	•	5-6	•	I/M	This study

SS, secretary signal sequence; EGF, EGF-like domain; RR, repeat regions; THR, the C terminal hydrophobic region. Ref.: references. YN represented isolates from Yunnan Provinces in China. • indicates identical amino acid residues compared to the Salvador I strain.
*, #, $, &, @ represented amino acid residues 210, 212, 216, 223, 224 reported in reference 26, respectively.

ISSN: 1756-3305