Table 1 Clinical manifestations and laboratory abnormalities found in canine leishmaniosis due to L. infantum
From: LeishVet guidelines for the practical management of canine leishmaniosis
Clinical manifestations | Laboratory abnormalities |
|---|---|
General ○ Generalized lymphadenomegaly ○ Loss of body weight ○ Decreased or increased appetite ○ Lethargy ○ Mucous membranes pallor ○ Splenomegaly ○ Polyuria and polydypsia ○ Fever ○ Vomiting ○ Diarrhea (including chronic colitis) | Serum proteins and electrophoretogram ○ Hyperglobulinemia   Polyclonal beta and/or gammaglobulinemia ○ Hypoalbuminemia ○ Decreased albumin/globulin ratio |
Cutaneous â—‹ Non-pruritic exfoliative dermatitis with or without alopecia â—‹ Erosive-ulcerative dermatitis â—‹ Nodular dermatitis â—‹ Papular dermatitis â—‹ Pustular dermatitis â—‹ Onychogryphosis | CBC/Hemostasis â—‹ Mild to moderate non-regenerative anemia â—‹ Leukocytosis or leukopenia â—‹ Thrombocytopathy â—‹ Thrombocytopenia â—‹ Impaired secondary hemostasis and fibrinolysis |
Ocular â—‹ Blepharitis (exfoliative, ulcerative, or nodular) and conjunctivitis (nodular) â—‹ Keratoconjunctivitis, either common or sicca â—‹ Anterior uveitis/Endophtalmitis | Biochemical profile/urinalysis â—‹ Mild to severe proteinuria â—‹ Renal azotemia â—‹ Elevated liver enzyme activities |
Other â—‹ Mucocutaneous and mucosal ulcerative or nodular lesions (oral, genital and nasal) â—‹ Epistaxis â—‹ Lameness (erosive or non-erosive polyarthritis, osteomyelitis, polymyositis) â—‹ Atrophic masticatory myositis â—‹ Vascular disorders (systemic vasculitis, arterial thromboembolism) â—‹ Neurological disorders |