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Table 1 Clinical manifestations and laboratory abnormalities found in canine leishmaniosis due to L. infantum

From: LeishVet guidelines for the practical management of canine leishmaniosis

Clinical manifestations Laboratory abnormalities
General
Generalized lymphadenomegaly
Loss of body weight
Decreased or increased appetite
Lethargy
Mucous membranes pallor
Splenomegaly
Polyuria and polydypsia
Fever
Vomiting
Diarrhea (including chronic colitis)
Serum proteins and electrophoretogram
Hyperglobulinemia
  Polyclonal beta and/or gammaglobulinemia
Hypoalbuminemia
Decreased albumin/globulin ratio
Cutaneous
Non-pruritic exfoliative dermatitis with or without alopecia
Erosive-ulcerative dermatitis
Nodular dermatitis
Papular dermatitis
Pustular dermatitis
Onychogryphosis
CBC/Hemostasis
Mild to moderate non-regenerative anemia
Leukocytosis or leukopenia
Thrombocytopathy
Thrombocytopenia
Impaired secondary hemostasis and fibrinolysis
Ocular
Blepharitis (exfoliative, ulcerative, or nodular) and conjunctivitis (nodular)
Keratoconjunctivitis, either common or sicca
Anterior uveitis/Endophtalmitis
Biochemical profile/urinalysis
Mild to severe proteinuria
Renal azotemia
Elevated liver enzyme activities
Other
Mucocutaneous and mucosal ulcerative or nodular lesions (oral, genital and nasal)
Epistaxis
Lameness (erosive or non-erosive polyarthritis, osteomyelitis, polymyositis)
Atrophic masticatory myositis
Vascular disorders (systemic vasculitis, arterial thromboembolism)
Neurological disorders