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Table 5 Current treatment protocols for canine leishmaniosis [27]

From: LeishVet guidelines for the practical management of canine leishmaniosis

Drugs

Dosages

Main side effects

References

Meglumine antimoniate*

75-100 mg/kg once a day or 40-75 mg/kg twice a day for 4 weeks, S.C.**

Potential nephrotoxicity

Cutaneous abscesses/cellulitis

[52, 55, 57, 81–83]

Miltefosine*

2 mg/kg/once a day for 28 days P.O.

Vomiting Diarrhea

[83–85]

Allopurinol

10 mg/kg twice a day for at least 6-12 months P.O.

Xanthine urolithiasis

[51, 59, 86–89]

  1. *Registered for veterinary use in most European countries; both drugs are commonly recommended in combination with allopurinol.
  2. P.O.: per os; S.C.: subcutaneous
  3. **Treatment prolongation by 2-3 weeks may be considered if patient improvement is insufficient.