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Table 6 Treatment of canine leishmaniosis - recommended monitoring of clinicopathological parameters and serology including frequency of follow up [27].

From: LeishVet guidelines for the practical management of canine leishmaniosis

Parameters Frequency
Clinical history and complete physical examination
Routine laboratory tests:
Complete CBC, biochemical profile, serum electrophoresis (optional) and complete urinalysis including UPC in proteinuric dogs.
After the first month of treatment and then every 3-4 months during the first year. Later on, if the dog is fully recovered clinically with treatment, a recheck would be recommended every 6 months or once a year.
Serology* Not before 6 months after initial treatment and every 6 months or once a year thereafter.
Real time PCR Can optionally be carried out at the same time as serology. The full usefulness of this assay for follow up during treatment is currently undetermined.
  1. *Some dogs present a significant decrease in antibody levels (more than a two-fold dilutions difference between the first and the following samples) associated with clinical improvement within 6 months to 1 year of treatment. Other dogs might not have a decrease in antibody levels despite clinical improvement. In contrast, a marked increase of antibody levels (more than two-fold elevation between monitoring samples) should be interpreted as a marker of relapse, especially in dogs following the discontinuation of treatment [27].