Src kinase inhibition enhanced neuropathogenic E. coli K1 invasion of A. castellanii . The involvement of Src kinase in the invasion of pathogenic E. coli (meningitis isolate) into A. castellanii was determined. Untreated A. castellanii were used as 100% phagocytosis and levels of bacterial invasion in inhibitor-treated A. castellanii are shown as percentage change. Src kinase inhibitor, PP2 but not its inactive analog, PP3 exhibits a significant increase in bacterial invasion of A. castellanii (P < 0.05). Results represent the mean of three independent experiments performed in duplicate, bars represent standard error of the mean.