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Table 3 Larval recoveries from skin snips and blood-fed black flies of doxycycline and placebo treated volunteers

From: Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host

 

Mf

L1/L2

L3

Month a

Doxy b

n = 7

Placebo

n = 5

Doxy

n = 7 c

Placebo

n = 5

Doxy

n = 7

Placebo

n = 5

0

26d

(13-80)

25

(10-76)

52

(45-157)

124

(71-155)

703

(509-1214)

789

(396-941)

1

42

(32-148)

83

(31-221)

29

(3-178)

33

(7-69)

281

(150-607)

313

(226-516)

2

40

(8-92)

114

(15-192)

133

(28-524)

112

(42-294)

797

(211-1615)

666

(385-963)

3

13

(7-40)

27

(10-113)

678

(167-965)

390

(90-877)

709

(335-1070)

983

(487-1169)

4

9

(2-127)

63

(9-92)

397

(103-1218)

217

(118-625)

318

(71-593)

406

(247-542)

5

28

(4-83)

63

(4-105)

426

(201-1476)

575

(388-1128)

53

(17-320)

240

(116-504)

  1. a Month after treatment (Group 0 is pre-treatment)
  2. b Treatment with Doxycycline (200 mg/day) for 6 weeks
  3. c At 2 months post treatment only 6/7 doxycycline treated volunteers attended the follow-up meeting
  4. d Median (range)