Table 1 Comparison of the IC 50 values of tested drugs for S. haematobium and S. mansoni schistosomula at the 72 hours time point evaluated microscopically and for S. haematobium NTS additionally fluorimetrically with resazurin
From: Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula
Technique | Drug | IC50values (μM) (mean ± SD) | |
|---|---|---|---|
S. haematobium | S. mansoni | ||
Microscopy | Praziquantel | 1.5 ± 1.1 | 0.7 ± 0.1 |
Mefloquine | 0.5 ± 0.2 | 0.7 ± 0.1 | |
Artesunate | 1.4 ± 0.1 | 1.5 ± 0.6 | |
Metrifonate | 1.6 ± 0.0 | 0.8 ± 0.1 | |
Oxamniquine | 26.5 ± 3.4 | 11.8 ±0.0 | |
Resazurin | Praziquantel | <3.5 | ND |
Mefloquine | 6.4 | ND | |
Artesunate | 7.4 | ND | |
Metrifonate | 348.3 | ND | |
Oxamniquine | >322.2 | ND | |