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Table 1 Comparison of the IC 50 values of tested drugs for S. haematobium and S. mansoni schistosomula at the 72 hours time point evaluated microscopically and for S. haematobium NTS additionally fluorimetrically with resazurin

From: Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula

Technique Drug IC50values (μM) (mean ± SD)
S. haematobium S. mansoni
Microscopy Praziquantel 1.5 ± 1.1 0.7 ± 0.1
  Mefloquine 0.5 ± 0.2 0.7 ± 0.1
  Artesunate 1.4 ± 0.1 1.5 ± 0.6
  Metrifonate 1.6 ± 0.0 0.8 ± 0.1
  Oxamniquine 26.5 ± 3.4 11.8 ±0.0
Resazurin Praziquantel <3.5 ND
  Mefloquine 6.4 ND
  Artesunate 7.4 ND
  Metrifonate 348.3 ND
  Oxamniquine >322.2 ND
  1. IC50 values are calculated from three replicates at a concentration range of 1.1-90 μg/ml. ND: Not determined.