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Table 2 Gene ontology and description of significant differentially expressed genes (P < 0.05; > 2 fold change)

From: Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection

Affymetrix ID1

Genbank accession number

Fold Change2

SD3

P-value4

Description5

GO Molecular funtion6

GO Biological process7

Ssc.30381.1.A1_at

CO991016

361.988

84.148

0.039

Unknown

Ssc.17891.1.A1_at

CF175823

29.073

8.518

0.029

Unknown

Ssc.13408.1.A1_at

BI405159

19.229

5.72

0.030

Unknown

Ssc.10537.1.A1_at

BF711416

15.897

1.497

0.002

Unknown

Ssc.29577.1.A1_at

CO940471

14.279

0.259

0.006

Unknown

Ssc.24631.1.S1_at

CK461650

11.635

1.792

0.007

Formin 1

Protein binding

Cell adhesion

Ssc.31062.1.S1_at

AJ663560

8.047

1.593

0.021

Unknown

Ssc.28701.1.S1_at

BG895814

8.008

0.889

0.015

Sorbin and SH3 domain isoform 2, transcript variant 14

Receptor activity

Signaling pathway

Ssc.29538.1.A1_at

CO941727

7.984

0.567

0.020

Unknown

Ssc.10128.1.A1_at

BI399899

7.217

1.986

0.039

similar to H. sapiens SIX homebox 4

Unknown

Unknown

Ssc.16289.1.A1_at

U15437.1

5.927

1.945

0.047

Ig heavy chain variable VDJ region

Protein binding

Immune response

Ssc.16269.1.S1_at

U15523.1

2.919

0.594

0.047

Ig heavy chain variable VDJ region

Protein binding

Immune response

Ssc.15942.5.A1_x_at

U38202.1

2.571

0.398

0.044

   

Ssc.17872.1.A1_at

CF175649

5.731

1.428

0.047

COUP transcription factor 1 (COUP-TF1)

Transcription factor

Signaling pathway

Ssc.31126.1.A1_at

CO942136

5.391

0.792

0.035

Unknown

Ssc.29622.1.A1_at

CO942607

4.96

0.634

0.009

Unknown

Ssc.17942.1.A1_at

CF176409

4.605

0.287

0.020

Unknown

Ssc.31069.1.A1_s_at

BF712013

4.578

0.478

0.014

DAZ interacting protein 3, zinc finger

Protein binding

Ubiquitin-dependent protein catabolic process

Ssc.6157.1.A1_at

BQ597772

3.782

0.555

0.021

Zinc finger protein 521

Unknown

Unknown

Ssc.1411.1.S1_at

BM190304

3.586

0.152

0.013

Thrombospondin 4 (TSP-4)

Cation binding, protein binding

Cell adhesion

Ssc.7524.1.A1_at

BQ599075

3.397

0.719

0.033

Sk/Dkk-1 protein precursor

Protein binding

Signaling pathway

Ssc.8931.1.A1_at

BI398736

3.336

0.818

0.037

Angiopoietin-like protein 2 (Angptl2)

Unknown

Signaling pathway

Ssc.13693.1.A1_at

BQ603203

3.313

0.589

0.026

Unknown

Ssc.4707.1.A1_at

BI118246

3.271

0.917

0.049

H. sapiens kit ligand (KITLG)

Protein binding

Cell adhesion

Ssc.13265.1.A1_at

BQ605073

3.236

0.602

0.029

Unknown

Ssc.7967.1.A1_at

BQ599891

3.153

0.663

0.033

Unknown

Ssc.8871.2.A1_at

CK457442

2.929

0.711

0.043

Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Protein binding

Signaling pathway

Ssc.20473.2.S1_at

CK456061

2.909

0.139

0.001

Unknown

Ssc.20452.1.S1_at

BX670488

2.890

0.616

0.035

Keratin associated protein 26-1

Protein binding

Cell structure

Ssc.29030.1.S1_at

CO988330

2.838

0.499

0.032

Unknown

Ssc.26632.1.S1_at

CN155689

2.813

0.333

0.030

Tripartite motif protein 32

Protein binding

Cell differentiation, ubiquitin-dependent protein catabolic process

Ssc.24221.2.A1_at

BI181166

2.805

0.302

0.007

NADH-ubiquinone oxidoreductase

Enzymatic activity

Cell metabolism

     

18 kDa subunit

  

Ssc.428.10.S1_at

AB087975.1

2.767

0.181

0.027

T cell receptor alpha chain (TCR-alpha)

Receptor activity

Immune response

Ssc.17790.1.S1_at

AB087958.1

2.334

0.369

0.031

T cell receptor alpha chain (TCR-alpha)

Receptor activity

Immune response

Ssc.18884.1.A1_at

CF365209

2.67

0.083

0.008

Unknown

Ssc.25538.1.S1_at

BX918287

2.597

0.377

0.033

Zinc finger protein 502

Transcription factor

Transcription

Ssc.26587.1.A1_at

CN154795

2.592

0.334

0.030

Unknown

Ssc.20172.1.A1_at

BX676733

2.547

0.347

0.027

Tumor endothelial marker 8 isoform 3

Protein binding, receptor activity

Cell adhesion

Ssc.7090.1.A1_at

NM_214233.1

2.465

0.435

0.026

Thioltransferase (GLRX1)

Enzymatic activity

Stress

Ssc.13474.1.A1_at

BQ602423

2.454

0.405

0.022

Unknown

Ssc.8511.1.A1_at

BF703957

2.449

0.275

0.009

Sus scrofa mRNA,clone: OVRM10011A06, expressed in ovary

Unknown

Unknown

Ssc.30148.1.A1_at

CO987207

2.341

0.208

0.048

Rho-related BTB domain containing 3 (RHOBTB3)

Protein binding, receptor activity

Signaling pathway, ubiquitin-dependent protein catabolic process

Ssc.22336.1.S1_at

CF793417

2.302

0.366

0.023

Homeobox protein Hox-B7 (Hox-2C)

Transcription factor, protein binding

Transcription

Ssc.1377.2.S1_at

BI343023

2.264

0.19

0.016

Integrin alpha-8 (ITGA8)

Cation binding, protein binding, receptor activity

Cell differentiation, cell adhesion, signalling pathway

Ssc.29167.1.A1_at

CO950916

2.198

0.272

0.030

Rho GTPase activating protein 5

Protein binding

Cell adhesion

Ssc.13363.1.A1_at

BI404946

2.188

0.31

0.038

Ubiquitin carboxyl-terminal hydrolase 24

Protein binding

Ubiquitin-dependent protein catabolic process

Ssc.17370.1.A1_at

BX665583

2.186

0.266

0.014

Adrenergic, alpha-1B-, receptor (ADRA1B)

Protein binding, receptor activity

Signaling pathway

Ssc.22210.2.S1_at

CF788693

2.176

0.298

0.040

Unknown

Ssc.29565.1.A1_at

CO942018

2.168

0.308

0.025

Unknown

Ssc.19407.1.A1_at

CF359796

2.157

0.016

0.015

Unknown

Ssc.28265.1.A1_at

CN025977

2.143

0.376

0.035

Unknown

Ssc.26179.1.S1_at

BX922022

2.123

0.101

0.005

Midnolin (MIDN)

Protein binding

Transcription

Ssc.4848.1.S1_at

CF789770

2.123

0.182

0.031

Calponin 3, acidic, transcript variant 1

Cation binding, protein binding

Unknown

Ssc.20453.1.S1_at

BX675824

2.092

0.228

0.012

Laminin receptor 1

Receptor activity

Unknown

Ssc.14354.1.A1_at

BQ601965

2.079

0.093

0.047

HHEX gene for hematopoietically expressed homeobox

Transcription factor

Cell differentiation, signaling pathway

Ssc.942.1.S1_at

CK465005

2.061

0.165

0.012

Gap junction protein, alpha 1 (GJA1)

Protein binding

Cell adhesion, signaling pathway, immune response

Ssc.26933.1.S1_at

CN163387

2.036

0.000

0.007

Interleukin 1 receptor accessory protein-like 1 (IL1RAPL1)

Receptor activity

Immune response

Ssc.30263.1.A1_at

CO989398

2.033

0.300

0.039

Unknown

Ssc.16566.1.S1_at

BF078197

2.025

0.271

0.025

Lactase phlorizinhydrolase

Cation binding

Cell metabolism

Ssc.9748.1.A1_at

BI398784

−3.914

1.462

0.033

Unknown

  

Ssc.30189.1.A1_at

CO987781

−4.078

1.800

0.038

Pig DNA sequence from clone CH242-94D11 on chromosome 7

Unknown

Unknown

Ssc.8698.1.S1_at

CN163671

−10.246

0.151

0.010

Cadherin 11, type 2, OB-cadherin (osteoblast)

Cation binding, protein binding

Cell adhesion

Ssc.18866.1.A1_at

CF365015

−10.551

1.242

0.003

Unknown

Ssc.29259.1.A1_at

CO953119

−14.935

2.417

0.048

Zinc finger protein 567

Transcription factor

Transcription

  1. 1 Affymetrix ID identifies the probe based on Affymetrix accession number.
  2. 2 Fold change is the normalized average log2 ratio of infected/uninfected wild pigs (negative values denote dowregulation in infected animals).
  3. 3 SD is the standard deviation of the normalized average log2 ratio.
  4. 4 P-value determined from the average log2 ratio.
  5. 5 Description indicates a short description of the gene.
  6. 6 GO molecular function is the function of the gene according to GO entries.
  7. 7 GO biological process indicates the gene process according to GO entries.