Figure 1

Sequence alignment of TIR domains from several species. Representative sequences are show from: Homo sapiens (IL-1R, TLR2, and MyD88_[Hs]), Drosophila melanogaster (Toll4_[Dm]), Arabidopsis thaliana (TAO1_[At]) as well as the sequences from Entamoeba invadens (EIN_134280_[Ei]) and Entamoeba histolytica (thioredoxin_[Eh]). Colors correspond to secondary structure derived from 3D structures for representative TIR domains, Psipred predictions for EIN_134280_[Ei] and the 3D modeled structure for Thioredoxin_[Eh]: helixes are colored in red and sheets in yellow. The three highly conserved regions previously described in TIR domains[14] are highlighted as boxes 1 to 3. I-Tasser secondary structure assignments are shown at the bottom (H= helix, S= sheet).