Figure 2

The cartoon diagrams for the 3D structure of the SjGIPC3-PDZ domain. A. The SjGIPC3-PDZ domain is colored by secondary-structure elements (α-helices, cyan; β-strands, magenta; loops, salmon). B. A hydrophobic pocket was formed by the αB helix, the βB strand, and the carboxylate-binding loop. The hydrophobic amino acids within the pocket are highlighted in red. The residue F in the unique “GLGF” motif (here is “SF GL”) may affect the selection of the C-terminal tails of its partner proteins.