Infection of mice with tpx-2 -disrupted P. berghei. Parasite populations, including WT, TPx-2 WT and two TPx-2 KO populations (KO1 and KO2), were inoculated into mice, and the courses of parasite development in erythrocytes were observed. (A) Changes in parasitemia 6 days after infection (three mice per group). (B) Changes in gametocytemia 6 days after infection (four mice per group). Gametocyte numbers were shown as gametocytes/104 erythrocytes. Data show mean values of parasitemia percentage (A) and gametocyte number (B). *Significant difference in the days required for having the highest gametocyte number between WT and TPx-2 KO populations (P < 0.05; Student’s t-test).