Figure 2

Genes modulated during primary infestations of mice compared to tick-free mice. Gene expression was measured using PCR arrays at 12, 48, 72, and 96 hr p.i. during a primary exposure of BALB/cJ mice to I. scapularis nymphs. Significantly modulated genes were divided into biologically meaningful groups (Methods) to allow direct comparison between time points. Official gene symbols and fold changes for all results at 48, 72, and 96 hr p.i. are shown. No significant gene modulation was apparent at 12 hr p.i.