Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs

Table 1 Gene ontology results from genes upregulated during primary infestation.

Cluster	Term	PValue
Host response	Chemokine activity	0.005
	Chemokine receptor binding	0.005
	Chemokine signaling pathway	0.014
	Small chemokine, interleukin-8-like	0.0031
	CXC chemokine	0.047
	Cytokine	0.0009
	Cytokine activity	0.0041
	Cytokine-cytokine receptor interaction	0.015
	NOD-like receptor signaling pathway	0.001
	Extracellular region part	0.025
	Extracellular space	0.0036
	Secreted	0.0097
	Immune response	0.008
	Inflammatory response	0.0012
	Defense response	0.0003
	Response to wounding	0.0039
	Taxis	0.0007
	Chemotaxis	0.0007
	Locomotory behavior	0.0007
	Behavior	0.006
Biomineral formation	Biomineral formation	0.024

Significant gene ontology terms from genes upregulated at any time point during primary infestation of mice with I. scapularis nymphs are shown grouped into clusters based on the functional annotation clustering tool available from DAVID. Terms in the host response cluster have been grouped by similarity.

ISSN: 1756-3305