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Table 2 Gene ontology results from genes downregulated during primary infestation.

From: Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs

Cluster

Term

PValue

Nucleotide metabolism

Cell morphogenesis

0.039

and transcription

DNA binding

0.020

 

Positive regulation of biosynthetic process

0.025

 

Positive regulation of cellular biosynthetic process

0.022

 

Positive regulation of gene expression

0.046

 

Positive regulation of macromolecule biosynthetic process

0.022

 

Positive regulation of macromolecule metabolic process

0.042

 

Positive regulation of nitrogen compound metabolic process

0.014

 

Positive regulation of nucleobase, nucleoside, nucleotide and nucleic- acid metabolic process

0.010

 

Positive regulation of RNA metabolic process

0.032

 

Positive regulation of transcription

0.036

 

Positive regulation of transcription from RNA polymerase II- promoter

0.025

 

Positive regulation of transcription, DNA-dependent

0.032

 

Regulation of RNA metabolic process

0.025

 

Regulation of transcription

0.046

 

Regulation of transcription from RNA polymerase II promoter

0.027

 

Regulation of transcription, DNA-dependent

0.027

 

Sequence-specific DNA binding

0.018

 

Tissue morphogenesis

0.026

SEFIR domain

IPR013568:SEFIR (IL-17R domain)

0.026

  1. Significant gene ontology terms from genes downregulated at any time point during primary infestation of mice with I. scapularis nymphs are shown grouped into clusters based on the functional annotation clustering tool available from DAVID.