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Table 1 Activity of combinations of standard anthelmintics against T. muris in vitro, expressed as IC 50 values and combination indices (CI)

From: Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo

Drug activity against T. muris adult worms in vitro

Single drug

IC 50 s (μg/ml) (r)

Albendazole

> 200 (0.40)§

Mebendazole

> 200 (0.58)

Levamisole

16.5 (1.0)§

Pyrantel pamoate

34.1 (0.99)§

Ivermectin

> 200 (0.40)

Drug combination

CI at IC 50

Albendazole-mebendazole

< 0.001

Albendazole-levamisole

0.12

Albendazole-pyrantel pamoate

0.11

Albendazole-ivermectin

< 0.001

Mebendazole-levamisole

0.04

Mebendazole-pyrantel pamoate

0.12

Mebendazole-ivermectin

< 0.001

Levamisole-pyrantel pamoate

0.007

Levamisole-ivermectin

0.12

Pyrantel pamoate-ivermectin

0.14

  1. IC50 median inhibitory concentration. r = linear correlation coefficient of the median-effect plot, indicating the goodness of fit. r ≥ 0.85 indicates a satisfactory fit. § IC50s of albendazole, levamisole, and pyrantel pamoate have been published elsewhere[13].
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Parasites & Vectors

ISSN: 1756-3305

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