Table 2 Mean number of larvae recovered at different time point in different organs of BALB/c knockout mice experimentally infected with human Loa loa. The numbers in brackets are mean recovery.
Strain | DPI | D2 | D5 | D10 | D15 | D20 | D30 | D40 | D50 | D60 | D70 | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nb of mice dissected | 2 | 1 | 2 | 2 | 4 | 2 | 1 | 14 | ||||
Nb of larvae recovered | 74 | 6 | 0 | 0 | 0 | 0 | 0 | 80 | ||||
Sub_Cut | 23 (11.5) | 0 | 0 | 0 | 0 | 0 | 0 | 23(1.6) | ||||
Muscle | 43(21.5) | 6 (6) | 0 | 0 | 0 | 0 | 0 | 49(3.5) | ||||
IL-4R KO | GO | 5(2.5) | 0 | 0 | 0 | 0 | 0 | 0 | 5(0.3) | |||
Peri-Cav | 2(1.0) | 0 | 0 | 0 | 0 | 0 | 0 | 2(0.1) | ||||
Plu-Cav | 1(0.5) | 0 | 0 | 0 | 0 | 0 | 0 | 1(0.1) | ||||
Heart/Lung | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
Total | 74(6.2) | 6(1.2) | 0 | 0 | 0 | 0 | 0 | |||||
Nb of mice dissected | 5 | 5 | 4 | 3 | 4 | 3 | 3 | 4 | 3 | 34 | ||
Nb of larvae recovered | 236 | 109 | 50 | 28 | 7 | 0 | 0 | 0 | 0 | 430 | ||
Sub_Cut | 188(37.6) | 64(12.8) | 27(6.8) | 14(4.7) | 3(0.8) | 0 | 0 | 0 | 0 | 296(8.7) | ||
Muscle | 29(5.8) | 32(6.4) | 8(2.0) | 2(0.7) | 2(0.5) | 0 | 0 | 0 | 0 | 73(2.1) | ||
IFN-γ KO | GO | 7(1.4) | 2(0.4) | 2(0.5) | 1(0.3) | 2(0.5) | 0 | 0 | 0 | 0 | 14(0.4) | |
Peri-Cav | 10(2.0) | 4(0.8) | 5(1.3) | 6(2.0) | 0 | 0 | 0 | 0 | 0 | 25(0.7) | ||
Plu-Cav | 2(0.4) | 5(1.0) | 5(1.3) | 4(1.3) | 0 | 0 | 0 | 0 | 0 | 16(0.5) | ||
Heart/Lung | 0 | 2(0.4) | 3(0.8) | 1(0.3) | 0 | 0 | 0 | 0 | 0 | 6(0.2) | ||
Total | 236(7.9) | 109(3.6) | 50(2.1) | 28(1.6) | 7(0.3) | 0 | 0 | 0 | 0 | |||
Nb of mice dissected | 3 | 3 | 3 | 4 | 4 | 4 | 2 | 2 | 25 | |||
Nb of larvae recovered | 84 | 62 | 76 | 23 | 25 | 11 | 2 | 283 | ||||
Sub_Cut | 58(19.3) | 25(8.3) | 31(10.3) | 10(2.5) | 8(2.0) | 3(0.8) | 2(1) | 0 | 137(5.5) | |||
Muscle | 22(7.3) | 32(10.7) | 29(9.7) | 10(2.5) | 11(2.8) | 8(2.0) | 0 | 0 | 112(4.5) | |||
IFN-γ/IL-5 DKO | GO | 0 | 0 | 2(0.7) | 0 | 1(0.3) | 0 | 0 | 0 | 3(0.1) | ||
Peri-Cav | 4(1.3) | 5(1.7) | 7(2.3) | 2(0.5) | 5(1.3) | 0 | 0 | 0 | 23(0.9) | |||
Plu-Cav | 0 | 0 | 6(2.0) | 1(0.3) | 0 | 0 | 0 | 0 | 7(0.3) | |||
Heart/Lung | 0 | 0 | 1(0.3) | 0 | 0 | 0 | 0 | 0 | 1(0.0) | |||
Total | 84(4.7) | 62(3.5) | 76(4.2) | 23(0.9) | 25(1.1) | 11(0.5) | 2(0.2) | 0 | ||||
Nb of mice dissected | 5 | 7 | 5 | 6 | 5 | 4 | 5 | 4 | 2 | 5 | 48 | |
Nb of larvae recovered | 195 | 80 | 100 | 60 | 62 | 20 | 2 | 5 | 0 | 0 | 524 | |
Sub_Cut | 145(29.0) | 36(5.1) | 34(6.8) | 19(3.2) | 12(2.4) | 7(1.8) | 0 | 1(0.3) | 0 | 0 | 254(4.9) | |
Muscle | 29(5.8) | 38(5.4) | 51(10.2) | 31(5.2) | 41(8.2) | 13(3.3) | 2(0.4) | 2(0.5) | 0 | 0 | 207(3.9) | |
IL-5 KO | GO | 5(1.0) | 2(0.3) | 0.0 | 2(0.3) | 0 | 0 | 0 | 0 | 0 | 0 | 9(0.2) |
Peri-Cav | 14(2.8) | 2(0.3) | 4(0.8) | 4(0.7) | 9(1.8) | 0 | 0 | 1(0.3) | 0 | 0 | 34(0.7) | |
Plu-Cav | 2(0.4) | 2(0.3) | 8(1.6) | 1(0.2) | 0 | 0 | 0 | 1(0.3) | 0 | 0 | 14(0.3) | |
Heart/Lung | 0 | 0 | 3(0.6) | 3(0.5) | 0 | 0 | 0 | 0 | 0 | 0 | 6(0.1) | |
Total | 195(6.5) | 80(1.9) | 100(3.3) | 60(1.7) | 62(1.8) | 20(0.8) | 2(0.1) | 5(0.2) | 0 | 0 | 524(1.6) | |
Nb of mice dissected | 1 | 3 | 3 | 4 | 4 | 3 | 3 | 2 | 2 | 2 | 27 | |
Nb of larvae recovered | 48 | 86 | 39 | 89 | 79 | 6 | 51 | 27 | 11 | 3 | 439 | |
Sub_Cut | 35(35) | 53(17.7) | 15(5.0) | 36(9.0) | 22(5.5) | 1(0.3) | 7(2.3) | 1(0.5) | 4(2.0) | 0.0 | 174(7.7) | |
Muscle | 10(10) | 23(7.7 | 23(7.6) | 31(7.8) | 34(8.5) | 5(1.7) | 36(12.0) | 23(11.5) | 3(1.5) | 2(1.0) | 190(6.9) | |
IL-4/IL-5 DKO | GO | 0 | 2(0.7) | 0 | 1(0.3) | 1(0.3) | 0 | 1(0.3) | 0 | 0 | 0 | 5(0.1) |
Peri-Cav | 2(2) | 6(2.0) | 1(0.3) | 10(2.5) | 7(1.8) | 0 | 4(1.3) | 1(0.5) | 0 | 0 | 31(0.8) | |
Plu-Cav | 1(1) | 2(0.7) | 0 | 9(2.3) | 12(3.0) | 0 | 3(1.0) | 1(0.5) | 1(0.5) | 0 | 29(0.9) | |
Heart/Lung | 0 | 0 | 0 | 2(0.5) | 3(0.8) | 0 | 0 | 1(0.5) | 3(1.5) | 1(0.5) | 10(0.4) | |
Total | 48(8) | 86(2.2) | 39(2.2) | 89(3.7) | 79(3.3) | 51(0.3) | 51(2.7) | 27(2.3) | 11(0.9) | 3(0.3) | 439(2.6) |