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Table 1 Reported human cases of N. mikurensis infection (until October 2011)

From: Prevalence of Neoehrlichia mikurensis in ticks and rodents from North-west Europe

Location

Case

Symptoms and clinical signs

Ref.

Germany

Male, 69yr

Immunosuppressive therapy

Episodes of fever, nonproductive cough, left thoracic pain, vein thrombosis, hypochromic anemia, reduced numbers of leukocytes, decreased percentage of lymphocytes, increased proportion of monocytes and elevated levels of CRP, microbiological analysis were negative.

[18]

Germany

Male, 57yr

Previously healthy

Headaches, fever, intracerebral and subarachnoid hemorrhage, aneurysm, elevated CRP, pulmonary infiltration, microbiological analyses were negative, elevated infection parameters. Patient died from septic multi-organ failure.

[18]

Sweden

Male, 77yr

Chronic lymphocytic leukemia

Transitory ischemic attack, hemolytic anemia, fever, erysipelas-like rash, transitory weakness of the left side of face and arm, hemolytic anemia, thrombocytopenia, thrombosis, pulmonary infiltration, increased proportion of monocytes and elevated levels of CRP, blood and other cultures were negative

[17]

Switzerland

Male, 61yr

CABG surgery

Malaise, fever, moderate dyspnea, elevated leukocytes/neutrophils, elevated CRP, microbiological analysis were negative

[20]

Czech Republic

Female 55 yr

Mantle Cell Lymphoma

Spiking fever, myalgias, arthralgias, erthema nodosum, elevated CRP, blood-, urine culture and pharyngeal swabs were negative. Antinuclear-, antinucleolar antigens and rheumatoid factor screens were negative.

[21]

Czech Republic

Male, 58yr

Liver transplantation and splenectomy

Spiking fever, extreme fatigue, joint pain, skin erythema, painful and stiffened subcutaneous veins, mild leukocytosis and elevated CPR, blood and urine cultures and pharyngeal swab were negative.

[21]