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Table 1 Number of tissue inhibitor of metalloproteases (TIMP) and netrin module (NTR)-containing protein sequences, respectively, identified in each sequence dataset and listed according to taxa

From: TIMPs of parasitic helminths – a large-scale analysis of high-throughput sequence datasets

  TIMPs (no. with SP) NTR-module containing proteins (no. with SP)
Nematodes   
Ascaris suum 3* (3) 2 (1)
Brugia malayi - 1 (1)
Dictyocaulus filaria 1 (1) 1 (−)
Necator americanus 8** (3) 1 (1)
Oesophagostomum dentatum 2 (2) 1 (−)
Trichinella spiralis - 1 (1)
Trichuris suis - 2 (−)
Wuchereria bancrofti - 2 (−)
Trematodes   
Clonorchis sinensis - 1 (−)
Fasciola gigantica - 2 (−)
Fasciola hepatica - 1 (−)
Opisthorchis viverrini - 4 (1)
Schistosoma haematobium 1*** (1) 5 (−)
Schistosoma japonicum - 1 (−)
Schistosoma mansoni - 1 (−)
Total 15 (10) 26 (5)
  1. The number of proteins containing a predicted N-terminal signal peptide (SP) is also indicated.
  2. *Of these, Ascaris suum GS_04796 was up-regulated in the reproductive tissue of the adult female, while GS_21732 was up-regulated in the muscular tissue of adult males.
  3. **Necator americanus NECAME_13168 and NECAME_07191 were up-regulated in infective L3s, while NECAME_08457 and NECAME_08458 were up-regulated in adult N. americanus, ***Schistosoma haematobium A_01727 was up-regulated in the adult male.