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Table 2 Severity of tissue damage caused by different Borrelia strains a

From: Pathogenic analysis of Borrelia garinii strain SZ isolated from northeastern China

  Day 30 after infection Day 60 after infection Day 90 after infection  
B31 SZ BO23 B31 SZ B31 SZ Control
Brain ++ +++ ++ ++ + ++
Heart ++ +++ ++ ++ + ++
Lung ++ ++ + + + +
Liver +++ ++ +++ ++ +++ +
Spleen +++ ++ ++ ++ ++ ++
Kidney +++ +++ +++ ++ ++ +
Joint ++ ++ + + +
  1. a +++ severe, ++ moderate, + mild, —absent.
  2. Three mice in each group were sacrificed at 30, 60, and 90 days after inoculation. Disease severity was assessed by histopathologic assessment of inflammatory cell infiltrates and necrosis extent in tissues. The differences in disease severity between B31 and SZ infected mice were significant in brain, heart, liver and spleen tissues (P <0.05) at 30 days after inoculation. At 60 and 90 days after inoculation, there were varying degrees of recovery.