Figure 1From: Loss of neurovirulence is associated with reduction of cerebral capillary sequestration during acute Babesia bovis infectionSequential evaluation of cerebral capillary sequestration during acute babesiosis. (A) The timing of biopsy correlated with changes in rectal temperature during infection. Animals infected with T2Bo_vir are in red, and animals infected with T2Bo_att are in blue. The red arrows at days 6 and 8 indicate the first and second biopsy for T2Bo_vir infected animals. The blue arrows at days 7 and 9–10 indicate the first and second biopsy, respectively, for T2Bo_att infected animals. (B) Representative photomicrographs of brain biopsies of either the T2Bo_vir or T2Bo_att infected group. First biopsy (panels 1 and 4) was taken one day following the onset of fever. Second biopsy (panels 2 and 5) was taken 2–3 days following the first biopsy. Panels 3 and 6 represent samples taken within one hour of death. (C) Levels of sequestration observed in brain biopsies. There is a significant difference in sequestration between first and second biopsies (p < 0.0001), as well as first biopsy and necropsy (p < 0.0001) for the T2Bo_vir group. A significant difference between the T2Bo_vir and T2Bo_att groups for second biopsy and necropsy (p < 0.05) was also observed.Back to article page