Table 3 IC ₅₀ values for eflornithine, melarsoprol, pentamidine and nifurtimox obtained with the T.b. gambiense 348BT wild type and the recombinant RLuc #2.1 strain assessed with EnduRen, CellTiter-Glo and resazurin

5 x 10³

eflornithine^b

n.a.

1.0 ± 0.4

1.1 ± 0.4

1.0 ± 0.5

1.1 ± 0.6

1.4 ± 0.4

melarsoprol^c

n.a.

5.5 ± 2.1

4.5 ± 2.2

5.0 ± 1.9

6.3 ± 3.0

6.5 ± 2.3

pentamidine^c

n.a.

40.1 ± 11.1

43.6 ± 10.3

41.1 ± 7.5

67.5 ± 11.1

64.1 ± 13.6

nifurtimox^c

n.a.

334 ± 47

274 ± 93

380 ± 84

437 ± 139

410 ± 132

2 x 10⁴

eflornithine^b

n.a.

2.8 ± 0.5

3.0 ± 0.7

2.6 ± 1.0

2.6 ± 0.9

2.9 ± 0.7

melarsoprol^c

n.a.

11.0 ± 3.2

12.0 ± 2.8

11.5 ± 2.6

8.9 ± 2.2

11.9 ± 2.6

pentamidine^c

n.a.

47.5 ± 8.1

43.7 ± 10.8

48.9 ± 9.1

74.7 ± 12.3

72.5 ± 6.3

nifurtimox^c

n.a.

700 ± 63

670 ± 78

720 ± 75

751 ± 174

768 ± 125