Figure 4

Oxygen consumption rates (OCR) of uninfected cells, infected cells and free parasites preparations. (Top panel) Comparison of OCR for uninfected HBMEC cells (0 suffix, n =10), HBMEC cells 1 hr post infection (1 suffix, n = 8) and HBMEC cells 24 hr post infection (24 suffix, n = 6) with various exogenous metabolic substrates. Key: Basal, no substrate; Glu, 10 mM D-glucose; TMPD, 10 mM glucose + TMPD/ascorbate redox couple. (Bottom Panel) Comparison of OCR for uninfected K562 cells (0 suffix, n =10), K562 cells 1 hr post infection (1 suffix, n = 8) and K562 cells 24 hr post infection (24 suffix, n = 10) with various exogenous metabolic substrates. Key as for top panel. Data is represented in the box and whisker plots as follows: box, 25% to 75% quartile; bar, 50% quartile (median); whiskers, minimum and maximum.