Parasite infection | Â | Body weights (g) | Weight of spleen (g) | Weight of the liver (g) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Treatments | Week 8 | Week 10 | % change | Week 8 | Week 10 | % change | Week 8 | Week 10 | % change | |
L. major | P | 18.2 ± 0.8 | 20.4 ± 1.4 | 12.1 | 0.14 ± 0.007 | 0.15 ± 0.012 | 7.14 | 0.81 ± 0.091 | 0.80 ± 0.084 | −1.26 |
PZQ | 18.0 ± 0.5 | 16.6 ± 1.4 | −7.77 | 0.20 ± 0.027 | 0.24 ± 0.009 | 20.00 | 0.84 ± 0.014 | 0.86 ± 0.025 | 2.13 | |
 | P + PZQ | 18.6 ± 0.5 | 20.2 ± 1.2 | 8.60 | 0.15 ± 0.005 | 0.15 ± 0.007 | 0.00 | 0.79 ± 0.015 | 0.77 ± 0.014 | −1.50 |
 | PBS | 18.4 ± 0.4 | 14.4 ± 1.1 | −21.7 | 0.19 ± 0.027 | 0.24 ± 0.008 | 26.32 | 0.84 ± 0.011 | 0.86 ± 0.014 | 2.15 |
S. mansoni | P | 18.0 ± 0.6 | 16.1 ± 1.1 | −10.6 | 0.20 ± 0.010 | 0.24 ± 0.009 | 20.00 | 1.59 ± 0.023 | 1.64 ± 0.012 | 3.14 |
 | PZQ | 18.0 ± 0.6 | 19.8 ± 0.9 | 10.0 | 0.17 ± 0.022 | 0.19 ± 0.011 | 11.76 | 0.83 ± 0.006 | 0.82 ± 0.004 | −1.26 |
 | P + PZQ | 18.6 ± 0.8 | 20.3 ± 0.6 | 9.10 | 0.16 ± 0.006 | 0.16 ± 0.005 | 0.00 | 0.83 ± 0.013 | 0.82 ± 0.049 | −1.38 |
 | PBS | 18.4 ± 0.9 | 14.5 ± 1.7 | −21.2 | 0.20 ± 0.025 | 0.25 ± 0.006 | 25.00 | 1.08 ± 0.011 | 1.11 ± 0.009 | 2.77 |
L. major + S. mansoni | P | 19.8 ± 0.2 | 18.2 ± 0.5 | −8.08 | 0.22 ± 0.006 | 0.25 ± 0.013 | 13.60 | 1.55 ± 0.041 | 1.58 ± 0.032 | 3.20 |
PZQ | 18.4 ± 0.3 | 17.0 ± 0.8 | −7.60 | 0.22 ± 0.009 | 0.24 ± 0.007 | 9.09 | 1.59 ± 0.012 | 1.61 ± 0.011 | 1.95 | |
 | P + PZQ | 18.4 ± 0.6 | 19.8 ± 0.4 | 7.60 | 0.19 ± 0.016 | 0.20 ± 0.012 | 5.26 | 0.82 ± 0.012 | 0.83 ± 0.013 | 1.22 |
 | PBS | 17.9 ± 0.9 | 14.4 ± 1.5 | −19.6 | 0.21 ± 0.007 | 0.27 ± 0.018 | 28.57 | 1.04 ± 0.014 | 1.08 ± 0.017 | 4.24 |
ANOVA | Main effect | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | F | 19.311 | 7.421 |  | 9.241 | 8.421 |  | 7.112 | 14.0214 |  |
 | p value | 0.0000 | 0.0005 |  | 0.0001 | 0.0004 |  | 0.0071 | 0.0000 |  |
 | Repeated measure |  |  |  |  |  |  |  |  |  |
 | F |  | 9.2114 |  |  | 7.5515 |  |  | 5.5544 |  |
 | p value |  | 0.0007 |  |  | 0.0021 |  |  | 0.0081 |  |