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Table 1 Mean (± SEM) body weight, weight of spleen and weight of the liver of BALB/c mice infected with L. major , S. mansoni and those co-infected with L. major+S. mansoni

From: Combination therapy using Pentostam and Praziquantel improves lesion healing and parasite resolution in BALB/c mice co-infected with Leishmania major and Schistosoma mansoni

Parasite infection   Body weights (g) Weight of spleen (g) Weight of the liver (g)
Treatments Week 8 Week 10 % change Week 8 Week 10 % change Week 8 Week 10 % change
L. major P 18.2 ± 0.8 20.4 ± 1.4 12.1 0.14 ± 0.007 0.15 ± 0.012 7.14 0.81 ± 0.091 0.80 ± 0.084 −1.26
PZQ 18.0 ± 0.5 16.6 ± 1.4 −7.77 0.20 ± 0.027 0.24 ± 0.009 20.00 0.84 ± 0.014 0.86 ± 0.025 2.13
  P + PZQ 18.6 ± 0.5 20.2 ± 1.2 8.60 0.15 ± 0.005 0.15 ± 0.007 0.00 0.79 ± 0.015 0.77 ± 0.014 −1.50
  PBS 18.4 ± 0.4 14.4 ± 1.1 −21.7 0.19 ± 0.027 0.24 ± 0.008 26.32 0.84 ± 0.011 0.86 ± 0.014 2.15
S. mansoni P 18.0 ± 0.6 16.1 ± 1.1 −10.6 0.20 ± 0.010 0.24 ± 0.009 20.00 1.59 ± 0.023 1.64 ± 0.012 3.14
  PZQ 18.0 ± 0.6 19.8 ± 0.9 10.0 0.17 ± 0.022 0.19 ± 0.011 11.76 0.83 ± 0.006 0.82 ± 0.004 −1.26
  P + PZQ 18.6 ± 0.8 20.3 ± 0.6 9.10 0.16 ± 0.006 0.16 ± 0.005 0.00 0.83 ± 0.013 0.82 ± 0.049 −1.38
  PBS 18.4 ± 0.9 14.5 ± 1.7 −21.2 0.20 ± 0.025 0.25 ± 0.006 25.00 1.08 ± 0.011 1.11 ± 0.009 2.77
L. major + S. mansoni P 19.8 ± 0.2 18.2 ± 0.5 −8.08 0.22 ± 0.006 0.25 ± 0.013 13.60 1.55 ± 0.041 1.58 ± 0.032 3.20
PZQ 18.4 ± 0.3 17.0 ± 0.8 −7.60 0.22 ± 0.009 0.24 ± 0.007 9.09 1.59 ± 0.012 1.61 ± 0.011 1.95
  P + PZQ 18.4 ± 0.6 19.8 ± 0.4 7.60 0.19 ± 0.016 0.20 ± 0.012 5.26 0.82 ± 0.012 0.83 ± 0.013 1.22
  PBS 17.9 ± 0.9 14.4 ± 1.5 −19.6 0.21 ± 0.007 0.27 ± 0.018 28.57 1.04 ± 0.014 1.08 ± 0.017 4.24
ANOVA Main effect          
  F 19.311 7.421   9.241 8.421   7.112 14.0214  
  p value 0.0000 0.0005   0.0001 0.0004   0.0071 0.0000  
  Repeated measure          
  F   9.2114    7.5515    5.5544  
  p value   0.0007    0.0021    0.0081