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Table 1 Characteristics of trials included in the meta-analysis

From: Blocking malaria transmission to Anopheles mosquitoes using artemisinin derivatives and primaquine: a systematic review and meta-analysis

 Location
  (Study year)
Participants Treatment arms Mosquitoes (numbers used) Mosquito infection method Ref.
Gambia* (2000) Children (1–9 yrs) Artesunate [a] + chloroquine [b]; chloroquine [b] Anopheles gambiae (1208) Membrane feeding [15]
Gambia (1999) Children Artesunate [a] + sulfadoxine-pyrimethamine [f]; sulfadoxine-pyrimethamine [f] Anopheles gambiae (3192) Membrane feeding [16]
Gambia (1998) Children Artesuante [g] + sulfadoxine-pyrimethamine [f]; sulfadoxine-pyrimethamine [f] Anopheles gambiae (2688) Membrane feeding [16]
Kenya (2003–4) Children (6 months–10 yrs) Sulfadoxine-pyrimethamine [h] + placebo [i]; artesunate [a] + sulfadoxine-pyrimethamine [h]; sulfadoxine-pyrimethamine [h] + Amodiaquine [j]; artemether-lumefantrine [k] Anopheles gambiae (3000) Membrane feeding [17]
Gambia (2002) Children (1-10 yrs) Artemether-lumefantrine [c]; chloroquine[d] + sulfadoxine-pyrimethamine [e] Anopheles gambiae (540) Membrane feeding [18]
USA** Adults Primaquine [l]; Sulfadiazine + pyrimethamine [m] Anopheles stephensi (30) Direct skin bite [19]
USA*** (1968) Adults (25 to 41 yrs) Primaquine [l]; pyrimethamine [n] Anopheles stephensi (163) Direct skin bite [20]
  1. a = 4 mg/kg for 3 days.
  2. b = 25 mg/kg over 3 days: 10 mg, 10 mg, 5 mg.
  3. c = Each dose: One half-tablet of co-artemether (20 mg artemether + 120 mg of lumefantrine) per 5 kg body weight up to 24 kg (two tablets).
  4. d = Three daily doses of 10 mg/kg.
  5. e = One half-tablet of SP (12.5 mg of pyrimethamine with 250 mg of sulfadoxine per half-tablet).
  6. f = One-half tablet of pyrimethamine-sulfadoxine (12.5 mg pyrimethamine + 250 mg sulfadoxine) for a body weight of 10 kg & a further one-quarter tablet for each 5 kg increase.
  7. g = 4 mg/kg immediate dose of artesunate.
  8. h = 25 mg/kg sulfadoxine and 1.25 mg/kg pyrimethamine as a single dose plus.
  9. i = placebo once daily for 3 days.
  10. j = 10 mg/kg for once daily for 3 days.
  11. k = administered as half a tablet (20 mg of artemether and 120 mg of lumefantrine) per 5 kg of body weight in a 6-dose.
  12. l = single dose of 45 mg of primaquine base.
  13. m = 500 mg of sulfadiazine every 6 hours for 5 days and 50 mg of pyrimethamine daily for 3 days.
  14. n = Pyrimethamine 50 mg daily for 3 days.
  15. *two parallel studies involving autologous plasma and control serum.
  16. **the study year is not mentioned in the article.
  17. ***two parallel studies involving two strains of P. falciparum. Ref. = References.