Skip to main content

Table 2 Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of each diagnostic assay using quadruplicate Kato-Katz thick smears as the reference standard for S. mansoni diagnosis and two urine filtrations as the reference standard for S. haematobium diagnosis

From: A new rapid diagnostic test for detection of anti-Schistosoma mansoni and anti-Schistosoma haematobium antibodies

Four Kato-Katz as reference standard Sensitivity (95% CI) Specificity (95% CI) NPV (95% CI) PPV (95% CI)
Single Kato-Katz thick smear (day 1) 50.0 (29.6–70.4) 100 (95.1–100) 88.7 (80.7–93.8) 100 (69.9–100)
Duplicate Kato-Katz thick smears 75.0 (52.9–89.4) 100 (95.1–100) 94.0 (86.9–97.5) 100 (69.2–100)
Single POC-CCA cassette (day 1) 75.0 (52.9–89.4) 53.2 (42.7–63.5) 89.3 (77.4–95.6) 29.0 (18.6–42.1)
Duplicate POC-CCA cassettes 75.0 (52.9–89.4) 46.8 (36.5–57.3) 88.0 (75.0–95.0) 26.4 (16.8–38.8)
Single SmCTF-RDT 75.0 (52.9–89.4) 34.0 (24.8–44.6) 84.2 (68.1–93.4) 22.5 (14.2–33.5)
Two urine filtrations as reference standard Sensitivity (95% CI) Specificity (95% CI) NPV (95% CI) PPV (95% CI)
Single urine filtration (day 1) 66.7 (24.1–94.0) 100 (95.9–100) 98.2 (93.2–99.7) 100 (39.6–100)
Single SmCTF-RDT 66.7 (24.1–94.0) 33.0 (24.6–42.6) 94.9 (81.4–99.1) 5.1 (1.6–13.1)
  1. The study was carried out in Azaguié M’Bromé, south Côte d’Ivoire between June and September 2011 and focussed on a subset of 118 preschool-aged children (<6 years of age).
  2. CI, confidence interval.