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Table 1 Characteristics of the 128Leishmania infantum strains studied

From: Genetic diversity and structure in Leishmania infantum populations from southeastern Europe revealed by microsatellite analysis

Origin Strains WHO code Periphery/Region-Prefecture/Province (District) Pathologya MONb K26 ampliconb MLMT profilec Structure K = 4d
TR(16) EP3* MHOM/TR/1994/EP3 Aegean-Izmir VL n.d. n.d. 35 pop2
  EP16* MCAN/TR/1996/EP16 Aegean-Manisa CanL n.d. n.d. 36 pop2
  EP43 MCAN/TR/2000/EP43 Aegean-Aydin(Kuşadası) CanL 98 870/940 37 pop4 (sub4A)
  EP44 MCAN/TR/2000/EP44 Aegean-Aydin(Kuşadası) CanL 98 870/940 37 pop4 (sub4A)
  EP49 MCAN/TR/2000/EP49 Aegean-Aydin(Kuşadası) CanL 98 870/940 37 pop4 (sub4A)
  EP50 MCAN/TR/2000/EP50 Aegean-Aydin(Kuşadası) CanL 98 870/940 38 pop4 (sub4A)
  EP53 MCAN/TR/2000/EP53 Aegean-Aydin(Kuşadası) CanL 98 870/940 39 pop4 (sub4A)
  EP55 MCAN/TR/2000/EP55 Aegean-Aydin(Kuşadası) CanL 98 870/940 40 pop4 (sub4A)
  EP56 MCAN/TR/2000/EP56 Marmara-Bilecik CanL 1 870/940 25 pop2
  EP57 MCAN/TR/2001/EP57 Aegean-Muğla CanL n.d. 870/940 25 pop2
  EP58 MCAN/TR/2001/EP58 Aegean-Muğla CanL n.d. 940 41 pop2
  EP68 MCAN/TR/2001/EP68 Aegean-Aydin(Kuşadası) CanL n.d. 940 41 pop2
  EP88 MCAN/TR/2003/EP88 Black Sea-Çorum CanL 1 626 42 pop3 (sub3B1)
  EP89 MHOM/TR/2003/EP89 Aegean-Manisa(Alaşehir) VL n.d. 870/940 43 pop2
  EP126 MCAN/TR/2005/EP126 Aegean -Muğla(Bodrum) CanL 1 870/940 13 pop2
  EP134 MCAN/TR/2007/EP134 Mediterranean-Hatay(Antakya) CanL 1 626 44 pop4 (sub4C1)
CY(23) CD1 MCAN/CY/2001/CD1 Limassol CanL 1 626 29 pop1 (sub1A)
  CD13 MCAN/CY/2003/CD13 Limassol CanL 1 626 29 pop1 (sub1A)
  CD21 MCAN/CY/2004/CD21 Paphos CanL 1 626 29 pop1 (sub1A)
  CD22 MCAN/CY/2004/CD22 Limassol CanL 1 626 29 pop1 (sub1A)
  CD34 MCAN/CY/2005/CD34 Limassol CanL 1 626 30 pop1 (sub1B)
  CD37 MCAN/CY/2005/CD37 Paphos CanL 1 626 29 pop1 (sub1A)
  CD40 MCAN/CY/2005/CD40 Paphos CanL 1 626 29 pop1 (sub1A)
  CD43 MCAN/CY/2005/CD43 Paphos CanL 1 626 29 pop1 (sub1A)
  CD44 cl.5e MCAN/CY/2005/CD44cl.5 Paphos CanL 1 626 31 pop1 (sub1B)
  CD48 MCAN/CY/2005/CD48 Limassol CanL 1 626 29 pop1 (sub1A)
  CD51 MCAN/CY/2005/CD51 Paphos CanL 1 626 29 pop1 (sub1A)
  CD57 MCAN/CY/2005/CD57 Nicosia CanL 1 626 29 pop1 (sub1A)
  CD62 MCAN/CY/2005/CD62 Paphos CanL 1 626 29 pop1 (sub1A)
  CD68 MCAN/CY/2005/CD68 Paphos CanL 1 626 29 pop1 (sub1A)
  CD74 MCAN/CY/2006/CD74 Famagusta CanL 1 626 29 pop1 (sub1A)
  CD63 MCAN/CY/2005/CD63 Limassol CanL 1 626 29 pop1 (sub1A)
  CD66 MCAN/CY/2005/CD66 Nicosia CanL 1 626 29 pop1 (sub1A)
  CD85 MCAN/CY/2006/CD85 Nicosia CanL 1 626 32 pop1 (sub1B)
  CD87 MCAN/CY/2006/CD87 Paphos CanL 1 626 29 pop1 (sub1A)
  CD88 MCAN/CY/2006/CD88 Paphos CanL 1 626 33 pop1 (sub1B)
  CD90 MCAN/CY/2006/CD90 Paphos CanL 1 626 29 pop1 (sub1A)
  CD91 MCAN/CY/2006/CD91 Paphos CanL 1 626 33 pop1 (sub1B)
  CD108 MCAN/CY/2006/CD108 Larnaca CanL 1 626 34 pop1 (sub1B)
BG(1) BG1 MCAN/BG/2008/BG1 Blagoevgrad CanL 1 940 11 pop2
GR(54) GH2* MHOM/GR/2001/GH2 Attica-Athens VL 1 870/940 1 pop2
  GH5* MHOM/GR/2001/GH5 Crete-Lasithi/Ag.Nikolaos VL 1 870/940 2 pop2
  GH8* MHOM/GR/2001/GH8 Attica-Athens VL 1 870/940 3 pop2
  GH9* MHOM/GR/2001/GH9 Attica-Athens VL 1 870/940 4 pop4 (sub4C1)
  GH10* MHOM/GR/2001/GH10 Attica-Athens VL 1 870/940 2 pop2
  GH11* MHOM/GR/2001/GH11 Attica-Athens VL 1 870/940 3 pop2
  GH13 MHOM/GR/2003/GH13 Crete-Heraklion VL 98 870/940 5 pop4 (sub4A)
  GH21 MHOM/GR/2004/GH21 Crete-Heraklion VL 1 870/940 6 pop2
  GH22 MHOM/GR/2004/GH22 Crete-Rethymno VL 98 870/940 5 pop4 (sub4A)
  GH23 MHOM/GR/2004/GH23 Crete-Rethymno VL 98 870/940 7 pop4 (sub4C1)
  GH24 MHOM/GR/2004/GH24 Attica-Athens VL 1 626 8 pop4 (sub4C2)
  GH26 MHOM/GR/2004/GH26 Crete-Lasithi/Sitia VL 1 870/940 9 pop2
  GH27 MHOM/GR/2005/GH27 Crete-Heraklion VL 1 940 10 pop2
  LEM2289 MHOM/GR/1990/LA1037 Attica-Athens VL 1 870/940 11 pop2
  PAPADO MHOM/GR/1980/PAPADO Attica-Athens VL 1 870/940 3 pop2
  GH49 MHOM/GR/2008/GH49 North Aegean Sea-Lesbos/Mytilene VL 1 870/940 2 pop2
  GH51 MHOM/GR/2008/GH51 Central Greece-Euboea/Halkida VL 1 940 12 pop2
  GH54 MHOM/GR/2009/GH54 Central Greece-Phthiotis(Lamia) VL 1 870/940 13 pop2
  GH55 MHOM/GR/2009/GH55 Crete-Heraklion VL 1 870/940 14 pop2
  GH56 MHOM/GR/2009/GH56 Peloponnese-Arcadia (Tripoli) VL 1 870/940 15 pop2
  GD3* MCAN/GR/2001/GD3 Crete-Heraklion CanL 98 870/940 16 pop4 (sub4C1)
  GD4* MCAN/GR/2001/GD4 Crete-Heraklion CanL 98 870/940 17 pop4 (sub4C1)
  GD9 MCAN/GR/2002/GD9 Crete-Heraklion CanL 1 870/940 18 pop4 (sub4C2)
  GD12 MCAN/GR/2003/GD12 Crete-Lasithi/Sitia CanL 1 870/940 2 pop2
  GD14 MCAN/GR/2003/GD14 Crete-Heraklion CanL 98 870/940 3 pop2
  GD17 MCAN/GR/2004/GD17 Crete-Heraklion CanL 98 870/940 5 pop4 (sub4A)
  GD18 MCAN/GR/2004/GD18 Crete-Heraklion CanL 1 626 19 pop4 (sub4C2)
  GD19 MCAN/GR/2004/GD19 Crete-Heraklion CanL 1 626 19 pop4 (sub4C2)
  GD20 MCAN/GR/2004/GD20 Crete-Heraklion CanL 1 870/940 11 pop2
  GD23 MCAN/GR/2004/GD23 Crete-Lasithi/Sitia CanL 1 940 2 pop2
  GD24 MCAN/GR/2004/GD24 Crete-Lasithi/Sitia CanL 1 870/940 2 pop2
  GD25 MCAN/GR/2004/GD25 Crete-Lasithi/Sitia CanL 1 940 2 pop2
  GD26 MCAN/GR/2004/GD26 Crete-Lasithi/Sitia CanL 1 870/940 2 pop2
  GD31 MCAN/GR/2005/GD31 Crete-Lasithi/Sitia CanL 1 870/940 2 pop2
  GD32 MCAN/GR/2005/GD32 Crete-Lasithi/Sitia CanL 1 940 2 pop2
  GD33 MCAN/GR/2005/GD33 Crete-Lasithi/Sitia CanL 1 870/940 2 pop2
  GD35 MCAN/GR/2005/GD35 Crete-Lasithi/Sitia CanL 98 870/940 5 pop4 (sub4A)
  GD36 MCAN/GR/2005/GD36 Crete-Lasithi/Sitia CanL 98 870/940 5 pop4 (sub4A)
  GD71 MCAN/GR/2006/GD71 Crete-Lasithi CanL 98 870/940 3 pop2
  GD102 MCAN/GR/2006/GD102 Attica (Rafina) CanL 98 870/940 3 pop2
  GD104 MCAN/GR/2006/GD104 Crete-Heraklion CanL 98 870/940 20 pop4 (sub4A)
  GD112 MCAN/GR/2006/GD112 Crete-Heraklion CanL 98 870/940 21 pop4 (sub4A)
  GD154 MCAN/GR/2008/GD154 Central Macedonia-Thessaloniki CanL 1 940 22 pop2
  GD167 MCAN/GR/2008/GD167 Thessaly-Trikala CanL 98 870/940 11 pop2
  GD192 MCAN/GR/2008/GD192 South Aegean-Dodecanese/Rhodes CanL 1 626/870/940 22 pop2
  GD201 MCAN/GR/2008/GD201 East Macedonia-Drama CanL 1 870/940 23 pop2
  GD204 MCAN/GR/2009/GD204 East Macedonia-Kavala CanL 1 870/940 24 pop2
  GD210 MCAN/GR/2009/GD210 Epirus-Ioannina/Dodoni CanL 1 626 25 pop2
  GD211 MCAN/GR/2009/GD211 Peloponnese-Argolis CanL 98 870/940 3 pop2
  GD220 MCAN/GR/2009/GD220 West Greece-Achaea CanL 1 940 26 pop2
  GD221 MCAN/GR/2009/GD221 Epirus-Arta CanL 1 626 25 pop2
  GD223 MCAN/GR/2009/GD223 Ionian Islands-Corfu(Kerkyra) CanL 1 626/940 27 pop4 (sub4C2)
  GD229 MCAN/GR/2009/GD229 South Aegean-Cyclades CanL 1 940 13 pop2
  GD237 MCAN/GR/2010/GD237 Central Macedonia-Imathia CanL 1 940 28 pop2
AL(5) AH2 MHOM/AL/2006/AH2 unknown VL 1 870/940 52 pop2
  AH4 MHOM/AL/2006/AH4 unknown VL 1 870/940 11 pop2
  LEM3962 MHOM/AL/2000/516LEZH Tirana VL 1 870/940 53 pop4 (sub4B)
  AD16 MCAN/AL/2004/AD16 unknown CanL 1 n.d. 54 pop2
  LEM3894 MCAN/AL/98/C78L574 Tirana CanL 1 870/940 54 pop2
HR(10) Lu MCAN/HR/2009/Lu Unknown CanL 1 626 45 pop3 (sub3B2)
  Ne MCAN/HR/2009/Ne Cetina(Brač) CanL 1 626 46 pop3 (sub3B2)
  Me MCAN/HR/2009/Me Cetina(Makarska) CanL 1 626 47 pop3 (sub3B2)
  Mr MCAN/HR/2008/Mr unknown CanL 1 626 48 pop4 (sub4B)
  GS MCAN/HR/2009/GS unknown CanL 1 626 49 pop4 (sub4B)
  Ć MCAN/HR/2009/Ć unknown CanL 1 626 47 pop3 (sub3B2)
  U MCAN/HR/2009/U Dubrava(Korčula) CanL 1 626 48 pop4 (sub4B)
  Pa MCAN/HR/2009/Pa Dubrava(Korčula) CanL 1 626 50 pop4 (sub4B)
  SO MCAN/HR/2011/SO Dubrovnik CanL 1 626 45 pop3 (sub3B2)
  AL MCAN/HR/2011/AL Split CanL 1 626 51 pop3 (sub3B1)
FR(3)R LG1* MHOM/FR/1996/LEM75 Cévennes VL 1 626 69 pop3 (sub3B1)
  LG2* MHOM/FR/1995/LPN114 Côte d’Azur VL 1 626 70 pop3 (sub3B1)
  LG4* MHOM/FR/1997/LSL29 Cévennes CL 1 626 71 pop3 (sub3B1)
ES(11)R LLM-1139* MCAN/ES/2002/LLM-1139 Ibiza CanL 1 626 55 pop3 (sub3A)
  LLM-1228* MCAN/ES/2003/LLM-1228 Ibiza CanL 1 626 56 pop3 (sub3A)
  LLM-1241* MCAN/ES/2003/LLM-1241 Ibiza CanL 1 626 57 pop3 (sub3A)
  PMI* MHOM/ES/1993/PM1 Majorca VL 1 626 58 pop3 (sub3A)
  LLM-981* MHOM/ES/2001/LLM-981 Majorca VL 1 626 59 pop3 (sub3A)
  LLM-1008* MCAN/ES/2001/LLM-1008 Majorca CanL 1 626 60 pop3 (sub3A)
  LLM-1150* MHOM/ES/2002/LLM-1150 Majorca CL(HIV+) 1 626 61 pop3 (sub3A)
  LLM-1038* MCAN/ES/2001/LLM-1038 Majorca CanL 1 626 62 pop3 (sub3B1)
  LLM-1116* MCAN/ES/2002/LLM-1116 Madrid CanL 1 626 63 pop3 (sub3B1)
  LLM-1136* MCAN/ES/2001/LLM-1136 Madrid CanL 1 626 64 pop3 (sub3B1)
  LLM-1181* MHOM/ES/2002/LLM-1181 Madrid VL(HIV+) 1 626 65 pop3 (sub3B1)
PT(5)R IMT184* MHOM/PT/1993/IMT184 Lisbon VL 1 626 65 pop3 (sub3B1)
  ΙΜΤ339* MCAN/PT/2003/IMT339 Lisbon CanL 1 626 66 pop3 (sub3B1)
  IMT205* MCAN/PT/1995/IMT205 Alentejo CanL 1 626 65 pop3 (sub3B1)
  IMT288* MHOM/PT/2002/IMT288 Alto Douro VL 1 626 67 pop3 (sub3B1)
  ΙΜΤ316* MCAN/PT/2003/IMT316 Lisbon CanL 1 626 68 pop3 (sub3B1)
  1. Rreference strains included for comparison, the number of strains per geographical source is given in parenthesis; *strains analyzed in previous studies [14, 15, 36, 52, 55, 61, 68]; TR, Turkey; CY, Cyprus; BG, Bulgaria; GR, Greece; AL, Albania; HR, Croatia; FR, France; ES, Spain; PT, Portugal; aVL, visceral leishmaniasis; CanL, canine leishmaniasis; CL (HIV+), cutaneous leishmaniasis (co-infection with HIV); bbased on MLEE and K26 typing; n.d. not done; cThe 71 microsatellite profiles shared between different strains are indicated in italics; dPopulation assignment at K = 4 by STRUCTURE analysis, sub-structuring upon re-analysis is shown in parenthesis; eL. infantum MON-1 clone isolated from a case of mixed infection with MON-1 and MON-37 strains [34, 36].