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Table 1 Geometric mean and percent control of on-animal flea counts in naturally infested homes when dogs and cats were treated with indoxacarb or fipronil (s)-methoprene based topical spot-on formulations

From: Evaluation of indoxacarb and fipronil (s)-methoprene topical spot-on formulations to control flea populations in naturally infested dogs and cats in private residences in Tampa FL. USA

Treatment group # dogs/cats   Days post-treatment1
    Day 0 Day 7 Day 14 Day 21 Day 28 – 30 Day 40 - 45 Day 54 - 60
Indoxacarb2 32/3 Geomean4 51.0a 1.1a 0.6a 1.3a 2.6a 0.3a 0.5a
  % control5   97.8 98.8 97.4 95.0 99.4 99.1
  % (#) pets with no fleas 0.0 48.6 71.4 40.0 20.0 71.4 77.1
(0/35) (17/35) (25/35) (14/35) (7/35) (25/35) (27/35)
Fipronil (s)-methoprene3 30/2 Geomean 28.1a 4.1b 6.4b 13.6b 14.2b 8.0b 12.7b
  % control   85.5 77.3 51.5 49.5 71.6 54.8
  % (#) pets with no fleas 0.0 15.6 15.6 9.4 6.3 21.9 15.6
    (0/32) (5/32) (5/32) (3/32) (2/32) (7/32) (5/32)
  1. 1Dogs and cats treated on day 0 and again between days 28 – 30.
  2. 2Dogs and cats were treated topically with indoxacarb (19.53% w/w; ACTIVYL® Merck Animal Health) according to label directions.
  3. 3Dogs were treated topically with fipronil (9.8% w/w)–(s)-methoprene (8.8% w/w) spot-on (Frontline®Plus; Merial) and cats were treated topically with fipronil (9.8% w/w)–(s)-methoprene (11.8% w/w) (Frontline®Plus; Merial) according to label directions.
  4. 4Geometric mean numbers of fleas in visual area counts on pets.
  5. 5{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts)/day 0 geometric mean animal area flea counts)} x 100
  6. a,bGeometric means in a column with unlike letter superscripts are significantly different (P values ≤0.0079).