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Table 1 Geometric mean and percent control of on-animal flea counts in naturally infested homes when dogs and cats were treated with indoxacarb or fipronil (s)-methoprene based topical spot-on formulations

From: Evaluation of indoxacarb and fipronil (s)-methoprene topical spot-on formulations to control flea populations in naturally infested dogs and cats in private residences in Tampa FL. USA

Treatment group

# dogs/cats

 

Days post-treatment1

   

Day 0

Day 7

Day 14

Day 21

Day 28 – 30

Day 40 - 45

Day 54 - 60

Indoxacarb2

32/3

Geomean4

51.0a

1.1a

0.6a

1.3a

2.6a

0.3a

0.5a

 

% control5

 

97.8

98.8

97.4

95.0

99.4

99.1

 

% (#) pets with no fleas

0.0

48.6

71.4

40.0

20.0

71.4

77.1

(0/35)

(17/35)

(25/35)

(14/35)

(7/35)

(25/35)

(27/35)

Fipronil (s)-methoprene3

30/2

Geomean

28.1a

4.1b

6.4b

13.6b

14.2b

8.0b

12.7b

 

% control

 

85.5

77.3

51.5

49.5

71.6

54.8

 

% (#) pets with no fleas

0.0

15.6

15.6

9.4

6.3

21.9

15.6

   

(0/32)

(5/32)

(5/32)

(3/32)

(2/32)

(7/32)

(5/32)

  1. 1Dogs and cats treated on day 0 and again between days 28 – 30.
  2. 2Dogs and cats were treated topically with indoxacarb (19.53% w/w; ACTIVYL® Merck Animal Health) according to label directions.
  3. 3Dogs were treated topically with fipronil (9.8% w/w)–(s)-methoprene (8.8% w/w) spot-on (Frontline®Plus; Merial) and cats were treated topically with fipronil (9.8% w/w)–(s)-methoprene (11.8% w/w) (Frontline®Plus; Merial) according to label directions.
  4. 4Geometric mean numbers of fleas in visual area counts on pets.
  5. 5{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts)/day 0 geometric mean animal area flea counts)} x 100
  6. a,bGeometric means in a column with unlike letter superscripts are significantly different (P values ≤0.0079).