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Table 2 Cytotoxicity and anti-MAYV activity of purified quercetin and its derivatives EtOAc and n -BuOH extracts, containing equal parts of these compounds

From: Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity

Substance

CC 50 a

CC 90 a

IC 50 b

IC 90 b

SIc

RPd

μg/ml

μg/ml

μg/ml

μg/ml

Guaijaverin

795 ± 54

53 ± 5

>100

>100

Nd

nd

Quercetin

941 ± 123

43 ± 4

10 ± 0.7

19 ± 0.7

94

5

Quercitrin

411 ± 46

41 ± 4

>100

>100

Nd

nd

Isoquercitrin + hyperin (1:1)

265 ± 19

135 ± 11

59 ± 0.2

105 ± 3

4

1

EtOAc

3116 ± 405

49 ± 5

5 ± 0.3

25 ± 3.5

623

4

n -BuOH

418 ± 47

64 ± 3

3 ± 0.2

5 ± 0.3

208

20

Ribavirin

523 ± 42

215 ± 6

62 ± 4

112 ± 8

8

nd

  1. a –50% and 90% cytotoxic concentration.
  2. b –50% and 90% inhibitory concentration of viral replication.
  3. c – Selectivity Index = CC50/IC50.
  4. d – Relative Potency = standard IC90 / substance IC90.
  5. nd – Not determined.