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Table 2 Cytotoxicity and anti-MAYV activity of purified quercetin and its derivatives EtOAc and n -BuOH extracts, containing equal parts of these compounds

From: Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity

Substance CC 50 a CC 90 a IC 50 b IC 90 b SIc RPd
μg/ml μg/ml μg/ml μg/ml
Guaijaverin 795 ± 54 53 ± 5 >100 >100 Nd nd
Quercetin 941 ± 123 43 ± 4 10 ± 0.7 19 ± 0.7 94 5
Quercitrin 411 ± 46 41 ± 4 >100 >100 Nd nd
Isoquercitrin + hyperin (1:1) 265 ± 19 135 ± 11 59 ± 0.2 105 ± 3 4 1
EtOAc 3116 ± 405 49 ± 5 5 ± 0.3 25 ± 3.5 623 4
n -BuOH 418 ± 47 64 ± 3 3 ± 0.2 5 ± 0.3 208 20
Ribavirin 523 ± 42 215 ± 6 62 ± 4 112 ± 8 8 nd
  1. a –50% and 90% cytotoxic concentration.
  2. b –50% and 90% inhibitory concentration of viral replication.
  3. c – Selectivity Index = CC50/IC50.
  4. d – Relative Potency = standard IC90 / substance IC90.
  5. nd – Not determined.