Table 2 Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts at 250 ppm (initial screening dosage) on Plasmodium falciparum oocyst
Blood sample number | Gametocytes per μL blood | Treatment*and concentration | Prevalence of infected mosquitoes% (infected/total examined) | Number of oocysts/mosquito (CI95) |
|---|---|---|---|---|
1 | 56 | control | 53 (10/19) | 1.79 (0.30-3.28) |
NA 250 ppm | 0 (0/22) | 0.00 | ||
control | 58 (15/26) | 3.23 (1.34-5.12) | ||
NA 250 ppm | 0 (0/15) | 0.00 | ||
9 | 64 | control | 71 (39/55) | 7.15 (5.10-9.19) |
NLA 250 ppm | 20 (09/44) | 0.32 (0.09-0.54) | ||
13 | 64 | control | 54 (21/39) | 1.95 (0.87-3.02) |
NLA 250 ppm | 12 (05/42) | 0.26 (0.00-0.52) | ||
4 | 128 | control | 55 (18/33) | 1.91 (0.91-2.91) |
NLA 250 ppm | 35 (08/23) | 0.57 (0.14-0.99) | ||
10 | 232 | control | 76 (32/42) | 15.69 (10.82-20.56) |
NLA 250 ppm | 76 (13/22) | 1.36 (0.54-2.19) | ||
13 | 64 | control | 45 (15/33) | 1.39 (0.59-2.20) |
NLE 250 ppm | 42 (13/43) | 2.67 (1.35-4.00) | ||
5 | 216 | control | 53 (09/17) | 18.88 (4.26-33.50) |
NLE 250 ppm | 65 (15/23) | 27.83 (10.20-39.45) | ||
10 | 232 | control | 71 (35/49) | 10.61 (7.16-14.06) |
NLE 250 ppm | 84 (31/37) | 20.92 (14.50-27.34) | ||
18 | 88 | control | 56 (14/25) | 2.28 (0.58-3.98) |
NFA 250 ppm | 10 (03/30) | 0.20 (0.00-0.45) | ||
3 | 120 | control | 67 (32/48) | 3.69 (2.28-5.09) |
NFA 250 ppm | 41 (29/70) | 1.84 (1.03-2.65) | ||
14 | 416 | control | 66 (31/32) | 63.59 (37.99-89.19) |
NFA 250 ppm | 88 (30/34) | 88.15 (60.08-116.21) | ||
8 | 96 | control | 61 (25/41) | 1.90 (1.11-2.70) |
GS 250 ppm | 58 (21/36) | 2.14 (1.05-3.23) | ||
2 | 104 | control | 58 (21/36) | 6.67 (3.74-9.59) |
GS 250 ppm | 41 (09/22) | 2.05 (0.63-3.46) | ||
7 | 112 | control | 71 (27/38) | 2.71 (1.55-3.87) |
GS 250 ppm | 71 (36/51) | 4.61 (3.14-6.07) |