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Table 2 Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts at 250 ppm (initial screening dosage) on Plasmodium falciparum oocyst

From: Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates in Anopheles coluzzii mosquitoes

Blood sample number Gametocytes per μL blood Treatment*and concentration Prevalence of infected mosquitoes% (infected/total examined) Number of oocysts/mosquito (CI95)
1 56 control 53 (10/19) 1.79 (0.30-3.28)
   NA 250 ppm 0 (0/22) 0.00
control 58 (15/26) 3.23 (1.34-5.12)
NA 250 ppm 0 (0/15) 0.00
9 64 control 71 (39/55) 7.15 (5.10-9.19)
NLA 250 ppm 20 (09/44) 0.32 (0.09-0.54)
13 64 control 54 (21/39) 1.95 (0.87-3.02)
NLA 250 ppm 12 (05/42) 0.26 (0.00-0.52)
4 128 control 55 (18/33) 1.91 (0.91-2.91)
NLA 250 ppm 35 (08/23) 0.57 (0.14-0.99)
10 232 control 76 (32/42) 15.69 (10.82-20.56)
NLA 250 ppm 76 (13/22) 1.36 (0.54-2.19)
13 64 control 45 (15/33) 1.39 (0.59-2.20)
NLE 250 ppm 42 (13/43) 2.67 (1.35-4.00)
5 216 control 53 (09/17) 18.88 (4.26-33.50)
NLE 250 ppm 65 (15/23) 27.83 (10.20-39.45)
10 232 control 71 (35/49) 10.61 (7.16-14.06)
NLE 250 ppm 84 (31/37) 20.92 (14.50-27.34)
18 88 control 56 (14/25) 2.28 (0.58-3.98)
NFA 250 ppm 10 (03/30) 0.20 (0.00-0.45)
3 120 control 67 (32/48) 3.69 (2.28-5.09)
NFA 250 ppm 41 (29/70) 1.84 (1.03-2.65)
14 416 control 66 (31/32) 63.59 (37.99-89.19)
NFA 250 ppm 88 (30/34) 88.15 (60.08-116.21)
8 96 control 61 (25/41) 1.90 (1.11-2.70)
GS 250 ppm 58 (21/36) 2.14 (1.05-3.23)
2 104 control 58 (21/36) 6.67 (3.74-9.59)
GS 250 ppm 41 (09/22) 2.05 (0.63-3.46)
7 112 control 71 (27/38) 2.71 (1.55-3.87)
   GS 250 ppm 71 (36/51) 4.61 (3.14-6.07)
  1. *NA: NeemAzal®; NLA: neem leaves EtOAc extract; NLE: neem leaves EtOH extract; NFA: neem fruits EtOAc extract; GS: Guiera senegalensis stem gall EtOAc extract.