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Table 5 Significantly up-regulated ( p < 0.05; FC > 2) detoxification genes in whole genome microarray comparison of Wad Medani resistant vs . Dongola colony

From: Insecticide resistance in Anopheles arabiensis in Sudan: temporal trends and underlying mechanisms

Gene

Vectorbase descriptor

FC min

FC max

N° probes

Cytochrome P450s

    

CYP6Z3

AGAP008217-RA

7.97

13.45

4

CYP6P3

AGAP002865-RA

6.73

14.99

4

CYP6M2

AGAP008212-RA

4.82

5.03

4

CYP4H24

AGAP013490-RA

4.50

 

1

CYP6P4

AGAP002867-RA

3.93

4.36

4

CYP6Z2

AGAP008218-RA

3.57

4.38

3

CYP6AG1

AGAP013511-RA

3.08

3.14

2

CYP6M3

AGAP008213-RA

2.80

2.82

3

CYP302A1

AGAP005992-RA

2.73

 

1

CYP9J5

AGAP012296-RA

2.67

2.71

4

CYP9K1

AGAP000818-RA

2.37

 

1

CYP4H19

AGAP000088-RA

2.32

4.37

4

CYP9L2

AGAP012850-RA

2.10

 

1

CYP4C28

AGAP010414-RA

2.05

2.97

4

CYP12F2

AGAP008021-RA

2.00

2.42

4

CYP6AK1

AGAP010961-RA

2.03

 

1

CYP325J1

AGAP001443-RA

3.72

3.81

3

Carboxylesterases

    

carboxylesterase

AGAP010912-RA

6.94

 

1

COEglt2H

AGAP010914-RA

6.68

 

1

COEJHE2E

AGAP005834-RA

3.06

4.01

3

COEJHE5E

AGAP005837-RA

4.65

10.22

2

COEAE2D

AGAP005757-RA

2.01

2.07

3

COE09941 - Putative Carboxylesterase

AGAP010915-RA

2.72

2.89

3

COE13O

AGAP011507-RA

2.34

2.58

4

COE09895 - Putative Carboxylesterase

AGAP010911-RA

2.06

2.26

4

Glutathione-S-transferases

    

GSTe4

AGAP009193-RA

15.60

23.31

4

GSTd1-5

AGAP004164-RA

2.24

2.29

4

GSTd3

AGAP004382-RA

2.23

2.50

4

  1. N° probes = number of significant probes for each gene on the microarray (maximum = 4).
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