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Figure 2 | Parasites & Vectors

Figure 2

From: An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Figure 2

Effect of indirubin analogues 11 and 17 on the cell-death of L. donovani promastigotes. Effect of compounds 11 (B) and 17 (C) on the cell-death of L. donovani promastigotes, incubated with the GI50 of each compound for 48 hrs. Cells were stained with AnnexinV-FITC (horizontal axis, FL1-H) and propidium iodide PI (vertical axis, FL2-H) to assess membrane fluidity perturbations (AnnexinV staining) and membrane impermeability. The samples were then analyzed by flow cytometry. DMSO was used as negative control (A).

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Parasites & Vectors

ISSN: 1756-3305

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